MIP-3 alpha (CCL20) active protein
Human MIP-3 alpha (CCL20)
NCBI and Uniprot Product Information
NCBI Description
This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Description
Function: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC 29213. Ref.8
Subunit structure: Binds to and activate CCR6.
Subcellular location: Secreted.
Tissue specificity: Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon.
Induction: By bacterial lipopolysaccharides (LPS), TNF and IFNG/IFN-gamma. Induced by phorbol myristate acetate (PMA) in U-937 cell line and bowes melanoma. Repressed by IL10/interleukin-10.
Post-translational modification: C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Research Articles on MIP-3 alpha (CCL20)
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Product Notes
The MIP-3 alpha (CCL20) ccl20 (Catalog #AAA691737) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MIP-3 alpha (CCL20) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ASNFDCCLGY TDRILHPKFI VGFTRQLANE GCDINAIIFH TKKKLS VCAN PKQTWVKYIV RLLSKKVKNM. It is sometimes possible for the material contained within the vial of "MIP-3 alpha (CCL20), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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