MCP-4 (CCL13) active protein
Human MCP-4 (CCL13)
NCBI and Uniprot Product Information
NCBI Description
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
Subcellular location: Secreted.
Tissue specificity: Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
Induction: By IL1/interleukin-1 and TNF.
Post-translational modification: One major form (form long), and two minor forms (short chain and medium chain) are produced by differential signal peptide cleavage. The medium chain is about 30-fold less active than the long chain.
Miscellaneous: This protein can bind heparin.
Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.
Mass spectrometry: Molecular mass is 9314±30 Da from positions 17 - 98. Determined by MALDI. Ref.3Molecular mass is 8760±30 Da from positions 22 - 98. Determined by MALDI. Ref.3Molecular mass is 8575±30 Da from positions 24 - 98. Determined by MALDI. Ref.3
Research Articles on MCP-4 (CCL13)
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Product Notes
The MCP-4 (CCL13) ccl13 (Catalog #AAA691757) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human MCP-4 (CCL13) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKL GKEI CADPKEKWVQ NYMKHLGRKA HTLKT. It is sometimes possible for the material contained within the vial of "MCP-4 (CCL13), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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