Testing Data
IL-36RA active protein
Human IL-36Ra
Gene Names
Il1f5; IL36RN; Il-1h3; Il1hy1; IL-36Ra; AI413231; Fil1delta
Reactivity
Species Reactivity: Human
Purity
Above 98% as determined by SDS-PAGE Analysis.
Synonyms
IL-36Ra; Human IL-36Ra; Recombinant Human IL-36RA; IL-36RA active protein
Host
E Coli
Reactivity
Species Reactivity: Human
Purity/Purification
Above 98% as determined by SDS-PAGE Analysis.
Sequence
VLSGALCFR MKDSALKVL YLHNNQLLA GGLHAEKVI KGEEISVVP NRALDASLS PVILGVQGG SQCLSCGTE KGPILKLEP VNIMELYLG AKESKSFTF YRRDMGLTS SFESAAYPG WFLCTSPEA DQPVRLTQI PEDPAWDAP ITDFYFQQC D
Biological Activity
Measured by its ability to inhibit IL-36gamma induced IL-6 production by human PBMCs.
Cell Type
Dendritic Cells
Preparation and Storage
At -20 degree C
Testing Data
Testing Data
Related Product Information for IL-36RA active protein
The IL-1 family is comprised of 11 structurally related ligands, including the recently re-named IL-36RA (IL-1F5), IL-36 alpha (IL-1F6), IL-36beta (IL-1F8), and IL-36gamma (IL-1F9). The interaction of IL-36 ligands with the IL-1Rrp2 receptor (IL-1R6) can induce various activities, including dendritic cell maturation and activation. IL-36RA can antagonize the NF-kappaB signaling induced by either IL-36 alpha , -beta or -gamma by binding to the IL-1Rrp2 receptor in a manner that prevents the initiation of functional signaling. Recombinant human IL-36RA is an E Coli derived 17 kDa protein containing 154 amino acid residues.
Product Categories/Family for IL-36RA active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
17,136 Da
NCBI Official Full Name
Interleukin-36 receptor antagonist protein
NCBI Official Synonym Full Names
interleukin 1 family, member 5 (delta)
NCBI Official Symbol
Il1f5
NCBI Official Synonym Symbols
IL36RN; Il-1h3; Il1hy1; IL-36Ra; AI413231; Fil1delta
NCBI Protein Information
interleukin-36 receptor antagonist protein; IL-1F5; IL-1L1; IL-1HY1; IL-1 delta; interleukin-1 HY1; interleukin-1 delta; interleukin-1 homolog 3; interleukin-1-like protein 1; interleukin-1 family member 5; interleukin 1 receptor antagonist homolog 1
UniProt Protein Name
Interleukin-36 receptor antagonist protein
UniProt Gene Name
IL36RN
UniProt Synonym Gene Names
Fil1d; Il1f5; Il1h3; Il1hy1; IL-1HY1; IL-1 delta; IL-1F5; IL-1H3; IL-1L1
UniProt Entry Name
I36RA_MOUSE
Uniprot Description
Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.
Research Articles on IL-36RA
Similar Products
Product Notes
The IL-36RA il36rn (Catalog #AAA695883) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-36Ra reacts with Species Reactivity: Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: VLSGALCFR MKDSALKVL YLHNNQLLA GGLHAEKVI KGEEISVVP NRALDASLS PVILGVQGG SQCLSCGTE KGPILKLEP VNIMELYLG AKESKSFTF YRRDMGLTS SFESAAYPG WFLCTSPEA DQPVRLTQI PEDPAWDAP ITDFYFQQC D. It is sometimes possible for the material contained within the vial of "IL-36Ra, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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