IL-17D active protein
Human IL-17D
Gene Names
IL17D; IL27; IL-27; IL-17D
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
IL-17D; Human IL-17D; Recombinant Human IL-17D; IL-17D active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPR EQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR Y LPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRS VYT EAYVTIPVGC TCVPEPE kDa DSINSSIDKQ GAKLLLGPND A PAGP
Sequence Length
142
Endotoxin Level
< 0.1 ng per ug of IL-17D
Biological Activity
Testing in progress.
Related Product Information for IL-17D active protein
IL-17D is a disulfide-linked homodimer of two 185 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17D has the ability to stimulate the production of IL-6, IL-8, and GM-CSF and inhibits hemopoiesis of myeloid progenitor cells in colony forming assays. Recombinant human IL-17D is a 40.5 kDa disulfide-linked homodimer of two 185 amino acid polypeptide chains.
Product Categories/Family for IL-17D active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
40.5 kDa
NCBI Official Full Name
BCRe18/ABL1e3 fusion protein
NCBI Official Synonym Full Names
interleukin 17D
NCBI Official Symbol
IL17D
NCBI Official Synonym Symbols
IL27; IL-27; IL-17D
NCBI Protein Information
interleukin-17D; interleukin 27
UniProt Protein Name
BCRe18/ABL1e3 fusion protein
UniProt Gene Name
BCR/ABL fusion
UniProt Entry Name
Q8TDA2_HUMAN
NCBI Description
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]
Uniprot Description
IL17D: Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells. Belongs to the IL-17 family.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13q11
Cellular Component: extracellular space
Molecular Function: cytokine activity
Biological Process: inflammatory response
Research Articles on IL-17D
Similar Products
Product Notes
The IL-17D bcr/abl fusion (Catalog #AAA691924) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-17D reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: APRAGRRPAR PRGCADRPEE LLEQLYGRLA AGVLSAFHHT LQLGPR EQAR NASCPAGGRP ADRRFRPPTN LRSVSPWAYR ISYDPARYPR Y LPEAYCLCR GCLTGLFGEE DVRFRSAPVY MPTVVLRRTP ACAGGRS VYT EAYVTIPVGC TCVPEPE kDa DSINSSIDKQ GAKLLLGPND A PAGP. It is sometimes possible for the material contained within the vial of "IL-17D, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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