IL-17B active protein
Human IL-17B
Gene Names
IL17B; NIRF; IL-20; IL-17B; ZCYTO7
Reactivity
Human
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
IL-17B; Human IL-17B; Recombinant Human IL-17B; IL-17B active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERN IEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP S RIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPP PPR TGPCRQRAVM ETIAVGCTCI F
Sequence Length
180
Endotoxin Level
< 0.1 ng per ug of IL-17B
Biological Activity
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.
Related Product Information for IL-17B active protein
IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.
Product Categories/Family for IL-17B active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
36.6 kDa
NCBI Official Full Name
interleukin-17B
NCBI Official Synonym Full Names
interleukin 17B
NCBI Official Symbol
IL17B
NCBI Official Synonym Symbols
NIRF; IL-20; IL-17B; ZCYTO7
NCBI Protein Information
interleukin-17B; interleukin 20; interleukin-20; cytokine Zcyto7; interleukin-17 beta; cytokine-like protein ZCYTO7; neuronal interleukin-17 related factor; neuronal interleukin-17-related factor
UniProt Protein Name
Interleukin-17B
UniProt Gene Name
IL17B
UniProt Synonym Gene Names
IL20; NIRF; ZCYTO7; IL-17B; IL-20
UniProt Entry Name
IL17B_HUMAN
NCBI Description
The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
Subcellular location: Secreted.
Tissue specificity: Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.
Sequence similarities: Belongs to the IL-17 family.
Research Articles on IL-17B
Similar Products
Product Notes
The IL-17B il17b (Catalog #AAA691747) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IL-17B reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERN IEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP S RIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPP PPR TGPCRQRAVM ETIAVGCTCI F. It is sometimes possible for the material contained within the vial of "IL-17B, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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