IGF-BP1 active protein
Human IGF-BP1
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Ref.20
Subunit structure: Binds equally well IGF1 and IGF2.
Subcellular location: Secreted.
Post-translational modification: Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis. Ref.14 Ref.18 Ref.20
Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
Sequence caution: The sequence AAA52540.1 differs from that shown. Reason: Frameshift at positions 55 and 71.
Research Articles on IGF-BP1
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Product Notes
The IGF-BP1 igfbp1 (Catalog #AAA692092) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IGF-BP1 reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MAPWQCAPCS AEKLALCPPV SASCSEVTRS AGCGCCPMCA LPLGAA CGVA TARCARGLSC RALPGEQQPL HALTRGQGAC VQESDASAPH An AEAGSPESP ESTEITEEEL LDNFHLMAPS EEDHSILWDA ISTYDGS KAL HVTNIKKWKE PCRIELYRVV ESLAKAQETS GEEISKFYLP NC NKNGFYHS RQCETSMDGE AGLCWCVYPW NGKRIPGSPE IRGDPNCQ IY FNVQN. It is sometimes possible for the material contained within the vial of "IGF-BP1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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