I-TAC (CXCL11) active protein
Human I-TAC (CXCL11)
NCBI and Uniprot Product Information
NCBI Description
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.
Subcellular location: Secreted.
Tissue specificity: High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.
Induction: By IFNG/IFN-gamma and IFNB1/IFN-beta. Induction by IFNG/IFN-gamma is enhanced by TNF in monocytes, dermal fibroblasts and endothelial cells, and by IL1/interleukin-1 in astrocytes.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Mass spectrometry: Molecular mass is 8303 Da from positions 22 - 94. Determined by MALDI. Ref.4
Sequence caution: The sequence AAB17374.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on I-TAC (CXCL11)
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Product Notes
The I-TAC (CXCL11) cxcl11 (Catalog #AAA691874) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human I-TAC (CXCL11) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF. It is sometimes possible for the material contained within the vial of "I-TAC (CXCL11), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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