GDNF active protein
Human GDNF
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene may be associated with Hirschsprung disease. [provided by RefSeq, Jun 2010]
Uniprot Description
Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. Ref.1
Subunit structure: Homodimer; disulfide-linked. Ref.1 Ref.11 Ref.14
Subcellular location: Secreted Ref.10.
Tissue specificity: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. Ref.2 Ref.12
Induction: By cAMP, 12-O-tetradecanoylphorbol-13-acetate (TPA) and FGF2. Ref.10
Involvement in disease: Hirschsprung disease 3 (HSCR3) [MIM:613711]: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.Note: The disease may be caused by mutations affecting the gene represented in this entry. Ref.15 Ref.16 Ref.17 Ref.19Congenital central hypoventilation syndrome (CCHS) [MIM:209880]: Rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.18
Sequence similarities: Belongs to the TGF-beta family. GDNF subfamily.
Research Articles on GDNF
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Product Notes
The GDNF gdnf (Catalog #AAA692028) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human GDNF reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MSPDKQMAVL PRRERNRQAA AANPENSRGK GRRGQRGKNR GCVLTA IHLN VTDLGLGYET KEELIFRYCS GSCDAAETTY DKILKNLSRN R RLVSDKVGQ ACCRPIAFDD DLSFLDDNLV YHILRKHSAK RCGCI. It is sometimes possible for the material contained within the vial of "GDNF, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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