FGF-5 active protein

Human FGF-5

Cat. Num. AAA692007

• Gene Names: FGF5; HBGF-5; Smag-82
• Reactivity: Human
• Purity: > 95% by SDS-PAGE and HPLC analyses
• Synonyms: FGF-5; Human FGF-5; Recombinant Human FGF-5; FGF-5 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 95% by SDS-PAGE and HPLC analyses
• Form/Format: Lyophilized
• Sequence: MAWAHGEKRL APKGQPGPAA TDRNPIGSSS RQSSSSAMSS SSASSS PAAS LGSQGSGLEQ SSFQWSPSGR RTGSLYCRVG IGFHLQIYPD G KVNGSHEAN MLSVLEIFAV SQGIVGIRGV FSNKFLAMSK KGKLHAS AKF TDDCKFRERF QENSYNTYAS AIHRTEKTGR EWYVALNKRG KA KRGCSPRV KPQHISTHFL PRFKQSEQPE LSFTVTVPEK KNPPSPIK SK IPLSAPRKNT NSVKYRLKFR FG
• Sequence Length: 268

• Endotoxin Level: < 0.1 ng per of FGF-17
• Biological Activity: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is <= 0.5 ng/ml, corresponding to a specific activity of >= 2 x 106 units/mg.

Related Product Information for FGF-5 active protein

FGF-5 is a secreted heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-5 binds to FGFR 1c and 2c, and plays a regulatory role in the hair growth cycle. Recombinant human FGF-5 is a 27.6 kDa protein consisting of 252 amino acid residues.

Product Categories/Family for FGF-5 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 73486655
• NCBI GeneID: 2250
• NCBI Accession #: NP_004455.2
• NCBI GenBank Nucleotide #: NM_004464.3
• UniProt Accession #: P12034; O75846; Q3Y8M3; Q8NF90; B2R554
• Molecular Weight: 27.5 kDa
• NCBI Official Full Name: fibroblast growth factor 5 isoform 1
• NCBI Official Synonym Full Names: fibroblast growth factor 5
• NCBI Official Symbol: FGF5
• NCBI Official Synonym Symbols: HBGF-5; Smag-82
• NCBI Protein Information: fibroblast growth factor 5; heparin-binding growth factor 5
• UniProt Protein Name: Fibroblast growth factor 5
• UniProt Gene Name: FGF5
• UniProt Synonym Gene Names: FGF-5; HBGF-5
• UniProt Entry Name: FGF5_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase

By similarity. Ref.10

Subunit structure: Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.10

Subcellular location: Secreted

Potential.

Tissue specificity: Expressed in neonatal brain.

Developmental stage: Can transform NIH 3T3 cells.

Sequence similarities: Belongs to the heparin-binding growth factors family.

Sequence caution: The sequence AAB60698.1 differs from that shown. Reason: Erroneous gene model prediction.