FGF-12 active protein

Human FGF-12

Cat. Num. AAA691973

• Gene Names: FGF12; FHF1; FGF12B
• Reactivity: Human
• Purity: > 90% by SDS-PAGE
• Synonyms: FGF-12; Human FGF-12; FGF12; FHF1; FGF12B; FGF-12 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Lyophilized
• Sequence: MSSHHHHHH SSGLVPRGSH MESKEPQLKG IVTRLFSQQG YFLQMHP DGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE YL YSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEG Q IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR RKSS GTPTM NGGKVVNQDS T
• Sequence Length: 181

• Label/Conjugation: His-Tag
• Biological Activity: Data not available.

Related Product Information for FGF-12 active protein

FGF-12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn't obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF-12 accumulated in the nucleus, but was not secreted. FGF-12 is involved in nervous system development and function. FGF-12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signaling and ion exchange. FGF-12 is a single, non-glycosylated polypeptide chain produced in E. coli, having a molecular weight of 22.6 kDa and containing 201 amino acids (1-181). The FGF12 is fused to a 20 amino acid His tag at the N-terminus.

Product Categories/Family for FGF-12 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 21614511
• NCBI GeneID: 2257
• NCBI Accession #: NP_004104.3
• NCBI GenBank Nucleotide #: NM_004113.5
• UniProt Accession #: P61328; O35339; P70376; Q8TBG5; Q92912; Q93001; B2R6B7; B2R976
• Molecular Weight: 27,399 Da
• NCBI Official Full Name: fibroblast growth factor 12 isoform 2
• NCBI Official Synonym Full Names: fibroblast growth factor 12
• NCBI Official Symbol: FGF12
• NCBI Official Synonym Symbols: FHF1; FGF12B
• NCBI Protein Information: fibroblast growth factor 12; FHF-1; FGF-12; myocyte-activating factor; fibroblast growth factor 12B; fibroblast growth factor FGF-12b; fibroblast growth factor homologous factor 1
• UniProt Protein Name: Fibroblast growth factor 12
• UniProt Gene Name: FGF12
• UniProt Synonym Gene Names: FGF12B; FHF1; FGF-12; FHF-1
• UniProt Entry Name: FGF12_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Probably involved in nervous system development and function.

Subunit structure: Interacts with the C-terminal region of SCN9A

By similarity.

Subcellular location: Nucleus

Probable.

Tissue specificity: Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures.

Sequence similarities: Belongs to the heparin-binding growth factors family.