Rabbit anti-Human LONP2 Polyclonal Antibody | anti-LONP2 antibody

LONP2 Antibody

Cat. Num. AAA9216600

• Gene Names: LONP2; LONP; LONPL
• Reactivity: Human
• Applications: Western Blot
• Synonyms: LONP2; Polyclonal Antibody; LONP2 Antibody; Purified Rabbit Polyclonal Antibody (Pab); anti-LONP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
• Sequence Length: 808

• Applicable Applications for anti-LONP2 antibody: Western Blot (WB)
• Application Notes: WB ~~1:1000
• Antigen Source: Human
• Antigen Type: A Synthesized Peptide
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(Anti-LONP2 Antibody at 1:1000 dilution + K562 whole cell lysateLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution.Predicted band size : 95 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)

Related Product Information for anti-LONP2 antibody

ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity). May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1.

Product Categories/Family for anti-LONP2 antibody

Cell Biology

References

De Walque S.,et al.Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases. Ota T.,et al.Nat. Genet. 36:40-45(2004). Martin J.,et al.Nature 432:988-994(2004). Bechtel S.,et al.BMC Genomics 8:399-399(2007). Kikuchi M.,et al.J. Biol. Chem. 279:421-428(2004).

NCBI and Uniprot Product Information

• NCBI GI #: 665821155
• NCBI GeneID: 83752
• NCBI Accession #: NP_001287877.1
• NCBI GenBank Nucleotide #: NM_001300948.1
• UniProt Accession #: Q86WA8; Q0D2H6; Q8N3B9; Q8NCE9; Q96K43; B7ZKL7
• Molecular Weight: 94617
• NCBI Official Full Name: lon protease homolog 2, peroxisomal isoform 2
• NCBI Official Synonym Full Names: lon peptidase 2, peroxisomal
• NCBI Official Symbol: LONP2
• NCBI Official Synonym Symbols: LONP; LONPL
• NCBI Protein Information: lon protease homolog 2, peroxisomal
• UniProt Protein Name: Lon protease homolog 2, peroxisomal
• UniProt Gene Name: LONP2
• UniProt Synonym Gene Names: Lon protease 2
• UniProt Entry Name: LONP2_HUMAN

NCBI Description

LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.

Protein type: Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: peroxisomal matrix; membrane; cytoplasm; peroxisome; nucleus

Molecular Function: peptidase activity; protein binding; enzyme binding; protease binding; serine-type endopeptidase activity; ATP-dependent peptidase activity; ATP binding; receptor binding

Biological Process: peroxisome organization and biogenesis; protein targeting to peroxisome; misfolded or incompletely synthesized protein catabolic process; protein import into peroxisome matrix; regulation of fatty acid beta-oxidation; protein processing; response to organic cyclic substance

Uniprot Description

LONP2: ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. Belongs to the peptidase S16 family.

Protein type: Protease; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: membrane; nucleus; peroxisomal matrix; peroxisome

Molecular Function: ATP binding; ATP-dependent peptidase activity; enzyme binding; peptidase activity; protease binding; protein binding; receptor binding; serine-type endopeptidase activity

Biological Process: misfolded or incompletely synthesized protein catabolic process; peroxisome organization and biogenesis; protein import into peroxisome matrix; protein processing; protein targeting to peroxisome; regulation of fatty acid beta-oxidation; response to organic cyclic substance