CD23, soluble Active Protein | CD23 active protein

Human CD23, soluble

Cat. Num. AAA692070

• Gene Names: FCER2; CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
• Reactivity: Human
• Purity: > 96%, by SDS-PAGE and HPLC analysis
• Synonyms: CD23; soluble; Human CD23; Recombinant Human sCD23; CD23 active protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: > 96%, by SDS-PAGE and HPLC analysis
• Form/Format: Lyophilized
• Sequence: MELQVSSGFV CNTCPEKWIN FQRKCYYFGK GTKQWVHARY ACDDME GQLV SIHSPEEQDF LTKHASHTGS WIGLRNLDLK GEFIWVDGSH V DYSNWAPGE PTSRSQGEDC VMMRGSGRWN DAFCDRKLGA WVCDRLA TCT PPASEGSAES MGPDSRPDPD GRLPTPSAPL HS
• Sequence Length: 320

• Endotoxin Level: < 0.1 ng per ug of sCD23
• Biological Activity: Measured by its ability to induce TNF-alpha production by human PBMCs.

Related Product Information for CD23 active protein

CD23, the low affinity receptor for IgE, belongs to the C-type lectin structural family and plays a role in the regulation of IgE synthesis and IgE mediated activities. It is found both as a transmembrane receptor protein and in a soluble form, which is generated by proteolytic cleavage of membrane bound CD23. The predominant soluble form of CD23 (sCD23) consists of 172 amino acids corresponding to the extracellular domain of the full length precursor. sCD23, in addition to binding IgE, also exerts a number of IgE independent activities, such as promoting the activation and differentiation of B-cells and stimulating the release of pro-inflammatory cytokines from monocytes. Recombinant human sCD23 is a 19.2 kDa non-glycosylated protein containing 172 amino-acid residues.

Product Categories/Family for CD23 active protein

Soluble receptors

NCBI and Uniprot Product Information

• NCBI GI #: 334085205
• NCBI GeneID: 2208
• NCBI Accession #: NP_001193948.2
• NCBI GenBank Nucleotide #: NM_001207019.2
• UniProt Accession #: P06734
• Molecular Weight: 19.2 kDa
• NCBI Official Full Name: low affinity immunoglobulin epsilon Fc receptor isoform b
• NCBI Official Synonym Full Names: Fc fragment of IgE, low affinity II, receptor for (CD23)
• NCBI Official Symbol: FCER2
• NCBI Official Synonym Symbols: CD23; FCE2; CD23A; IGEBF; CLEC4J; BLAST-2
• NCBI Protein Information: low affinity immunoglobulin epsilon Fc receptor; CD23 antigen; fc-epsilon-RII; lymphocyte IgE receptor; immunoglobulin E-binding factor; C-type lectin domain family 4, member J
• UniProt Protein Name: Low affinity immunoglobulin epsilon Fc receptor
• UniProt Gene Name: FCER2
• UniProt Synonym Gene Names: CD23A; CLEC4J; FCE2; IGEBF
• UniProt Entry Name: FCER2_HUMAN

NCBI Description

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subunit structure: Homotrimer. Ref.12

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note: Also exists as a soluble excreted form, sCD23. Ref.8 Ref.9

Post-translational modification: N- and O-glycosylated.The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sequence similarities: Contains 1 C-type lectin domain.

Sequence caution: The sequence AAA52433.1 differs from that shown. Reason: Erroneous gene model prediction.