BRAK (CXCL14) active protein
Human BRAK (CXCL14)
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactic for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays. Ref.2 Ref.8
Subcellular location: Secreted.
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte-derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes. Ref.1 Ref.2 Ref.8
Induction: Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS). Ref.1
Domain: The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. Ref.9
Post-translational modification: Ubiquitinated, followed by degradation by the proteasome. Ref.9
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Caution: It is uncertain whether Met-1 or Met-13 is the initiator.
Sequence caution: The sequence AAD38944.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on BRAK (CXCL14)
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Product Notes
The BRAK (CXCL14) cxcl14 (Catalog #AAA691850) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human BRAK (CXCL14) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: SKCKCSRKGP KIRYSDVKKL EMKPKYPHCE EKMVIITTKS VSRYRG QEHC LHPKLQSTKR FIKWYNAWNE KRRVYEE. It is sometimes possible for the material contained within the vial of "BRAK (CXCL14), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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