BD-1 (36aa) active protein
Human BD-1 (36aa)
Gene Names
DEFB1; BD1; HBD1; DEFB-1; DEFB101
Reactivity
Human
Purity
> 95% by SDS-PAGE and HPLC analyses
Synonyms
BD-1 (36aa); Human BD-1 (36aa); Recombinant Human BD-1 (36 a.a.); BD-1 (36aa) active protein
Host
E Coli
Reactivity
Human
Purity/Purification
> 95% by SDS-PAGE and HPLC analyses
Form/Format
Lyophilized
Sequence
DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK
Sequence Length
68
Endotoxin Level
< 0.1 ng per ug of BD-1
Biological Activity
Determined by its ability to chemoattract CD34+ dendritic cells using a concentration range of 100.0-1000.0 ng/ml.
Related Product Information for BD-1 (36aa) active protein
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. Beta-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Beta-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues. Recombinant Human BD-1 is a 3.9 kDa protein containing 36 amino acid residues.
Product Categories/Family for BD-1 (36aa) active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
3.9 kDa
NCBI Official Full Name
beta-defensin 1 preproprotein
NCBI Official Synonym Full Names
defensin, beta 1
NCBI Official Symbol
DEFB1
NCBI Official Synonym Symbols
BD1; HBD1; DEFB-1; DEFB101
NCBI Protein Information
beta-defensin 1; BD-1; beta-defensin-1
UniProt Protein Name
Beta-defensin 1
UniProt Gene Name
DEFB1
UniProt Synonym Gene Names
BD1; HBD1; BD-1; hBD-1
UniProt Entry Name
DEFB1_HUMAN
NCBI Description
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. This gene encodes defensin, beta 1, an antimicrobial peptide implicated in the resistance of epithelial surfaces to microbial colonization. This gene maps in close proximity to defensin family member, defensin, alpha 1 and has been implicated in the pathogenesis of cystic fibrosis. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Has bactericidal activity
By similarity.
Subcellular location: Secreted.
Tissue specificity: Plasma.
Sequence similarities: Belongs to the beta-defensin family.
Mass spectrometry: Molecular mass is 3928±0.5 Da from positions 33 - 68. Determined by ESI. Ref.5
Research Articles on BD-1 (36aa)
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Product Notes
The BD-1 (36aa) defb1 (Catalog #AAA691671) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human BD-1 (36aa) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: DHYNCVSSGG QCLYSACPIF TKIQGTCYRG KAKCCK. It is sometimes possible for the material contained within the vial of "BD-1 (36aa), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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