AITRL active protein

Human AITRL

Gene Names

TNFSF18; TL6; AITRL; GITRL; hGITRL

Reactivity

Human

Purity

> 98% by SDS-PAGE and HPLC analyses

Synonyms

AITRL; Human AITRL; Recombinant Human AITRL; AITRL active protein

Ordering
Cat. Num. AAA691626 For Research Use Only!

Host

E Coli

Reactivity

Human

Purity/Purification

> 98% by SDS-PAGE and HPLC analyses

Form/Format

Lyophilized

Sequence

ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI

Sequence Length

199

Endotoxin Level

< 0.1 ng per ug of AITRL

Biological Activity

Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1.0-10.0 ng/ml. Please Note: Results may vary with PBMC donors.

Related Product Information for AITRL active protein

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human soluble AITRL is a 14.3 kDa protein, containing 126 amino acid residues corresponding to the extracellular domain of AITRL.

Product Categories/Family for AITRL active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

NCBI GI #

157419142

NCBI GeneID

8995

NCBI Accession #

NP_005083.2

NCBI GenBank Nucleotide #

NM_005092.3

UniProt Accession #

Q9UNG2; O95852; Q6ISV1; A9IQG8

Molecular Weight

14.3 kDa

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 18

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 18

NCBI Official Symbol

TNFSF18

NCBI Official Synonym Symbols

TL6; AITRL; GITRL; hGITRL

NCBI Protein Information

tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 18

UniProt Gene Name

TNFSF18

UniProt Synonym Gene Names

AITRL; GITRL; TL6; AITRL; hGITRL

UniProt Entry Name

TNF18_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Ref.8 Ref.9

Subunit structure: Homodimer

By similarity. Homotrimer. Ref.9

Subcellular location: Cell membrane; Single-pass type II membrane protein Ref.8.

Tissue specificity: Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

Induction: Up-regulated after stimulation by bacterial lipopolysaccharides (LPS).

Sequence similarities: Belongs to the tumor necrosis factor family.

Caution: It is uncertain whether Met-1 or Met-23 is the initiator.

Sequence caution: The sequence AAH93986.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAI12033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAQ89227.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence BAG36082.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence EAW90937.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on AITRL

1. Serum GITRL levels were higher in SLE patients.

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Product Notes

The AITRL tnfsf18 (Catalog #AAA691626) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human AITRL reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLI YGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE L HVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI. It is sometimes possible for the material contained within the vial of "AITRL, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.