Fibroblast Growth Factor-20 Active Protein | FGF20 active protein

Recombinant Human Fibroblast Growth Factor-20

Cat. Num. AAA140879

• Gene Names: FGF20; RHDA2; FGF-20
• Purity: Greater than 97.0% as determined by SDS-PAGE.
• Synonyms: Fibroblast Growth Factor-20; Recombinant Human Fibroblast Growth Factor-20; FGF20 Human; Fibroblast Growth Factor-20 Human Recombinant; Fibroblast Growth Factor 20; FGF-20; RHDA2; FGF20; FGF20 active protein

• Host: E Coli
• Purity/Purification: Greater than 97.0% as determined by SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 um filtered solution in MOPS, (NH4)2SO4, DTT and EDTA.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: MHHHHHHAPL AEVGGFLGGL EGLGQQVGSH FLLPPAGERP PLLGERRSAA ERSARGGPGA AQLAHLHGIL RRRQLYCRTG FHLQILPDGS VQGTRQDHSL FGILEFISVA VGLVSIRGVD SGLYLGMNDK GELYGSEKLT SECIFREQFE ENWYNTYSSN IYKHGDTGRR YFVALNKDGT PRDGARSKRH QKFTHFLPRP VDPERVPELY KDLLMYT
• Sequence Length: 211

• Biological Activity: The ED50, as measured in a proliferation assay using mouse NR6R-3T3 cells, is less than 2.5ng/ml.
• Solubility: It is recommended to reconstitute the lyophilized FGF-20 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized FGF20 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FGF-20 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for FGF20 active protein

Introduction: Fibroblast growth factor 20 (FGF20) belongs to the FGF gene family and member of FGF-9 subfamily (based upon its structure). Human FGF20 has several receptors which include FGF R1c, FGF R2c, FGF R3b, FGF R3c and FGF R4. FGF20 is expressed a various cells, including dopaminergic neurons, fibroblasts, keratinocytes and breast epithelium, and numerous sites in the fetus.

Description: FGF20 Human Recombinant (1-211) produced in E Coli is a single, non-glycosylated, polypeptide chain containing 217 amino acids and having a molecular mass of 24kDa.The FGF-20 is fused to a 6 amino acid His tag [HHHHHH] at N-terminus and purified by proprietary chromatographic techniques.

Product Categories/Family for FGF20 active protein

Cytokines and Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 9789947
• NCBI GeneID: 26281
• NCBI Accession #: NP_062825.1
• NCBI GenBank Nucleotide #: NM_019851.2
• UniProt Accession #: Q9NP95; B2RPH5
• Molecular Weight: 23,499 Da
• NCBI Official Full Name: fibroblast growth factor 20
• NCBI Official Synonym Full Names: fibroblast growth factor 20
• NCBI Official Symbol: FGF20
• NCBI Official Synonym Symbols: RHDA2; FGF-20
• NCBI Protein Information: fibroblast growth factor 20
• UniProt Protein Name: Fibroblast growth factor 20
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF20
• UniProt Synonym Gene Names: FGF-20
• UniProt Entry Name: FGF20_HUMAN

Uniprot Description

FGF20: Neurotrophic factor that regulates central nervous development and function. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: extracellular region

Molecular Function: 1-phosphatidylinositol-3-kinase activity; growth factor activity; heparan sulfate proteoglycan binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; receptor binding

Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; negative regulation of neuron apoptosis; phosphoinositide-mediated signaling; positive regulation of cell proliferation; regulation of dopamine secretion; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Renal Hypodysplasia/aplasia 2