TARC active protein

TARC (human), (recombinant)

Cat. Num. AAA566092

• Gene Names: CCL17; TARC; ABCD-2; SCYA17; A-152E5.3
• Purity: >=98% (HPLC, Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm)
• Synonyms: TARC; TARC (human); (recombinant); TARC active protein

• Host: E Coli
• Purity/Purification: >=98% (HPLC, Reducing and Non-reducing SDS-PAGE, UV spectroscopy at 280 nm)
• Form/Format: White lyophilized (freeze-dried) powder. Lyophilized from 0.02% TFA. Sterile filtered

• Source Note: Non-glycosylated protein, containing 71 amino acids
• Endotoxin: <=1EU/ug protein measured by kinetic LAL analysis
• Biological Activity: The activity is determined by the ability to chemoattract human T cells which is typically observed at a concentration of 2-40ng/ml
• Reconstitution: When reconstituting the product, gently pipet and wash down the sides of the vial to ensure full recovery of the protein into solution. It is recommended to reconstitute the lyophilized product with sterile water at a concentration of 0.1mg/ml, which can be further diluted into other aqueous solutions
• Preparation and Storage: For long term storage, store at -20 degree C; It is recommended that a carrier protein (0.1% HSA or BSA) is added for long term storage; Centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20 degree C

Related Product Information for TARC active protein

Thymus and activation regulated chemokine (TARC), also known as CCL17, is a chemokine produced by thymus tissue constitutively and activated PBMCs (mainly DCs). TARC signals through the CCR4 receptor to induce chemotaxis of Th2 cells. TARC is thought to be important in asthma and allergic diseases, along with bacterial and viral infections.

Product Categories/Family for TARC active protein

Cellular Analysis; Cell Growth & Development; Stem Cells

NCBI and Uniprot Product Information

• NCBI GI #: 3024711
• NCBI GeneID: 6361
• UniProt Accession #: Q92583; Q2M287; A0N0Q9
• Molecular Weight: 94
• NCBI Official Full Name: C-C motif chemokine 17
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 17
• NCBI Official Symbol: CCL17
• NCBI Official Synonym Symbols: TARC; ABCD-2; SCYA17; A-152E5.3
• NCBI Protein Information: C-C motif chemokine 17; CC chemokine TARC; T cell-directed CC chemokine; small-inducible cytokine A17; thymus and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 17
• UniProt Protein Name: C-C motif chemokine 17
• UniProt Gene Name: CCL17
• UniProt Synonym Gene Names: SCYA17; TARC
• UniProt Entry Name: CCL17_HUMAN

NCBI Description

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL17: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR4 chemokine receptor binding; chemokine activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; multicellular organismal development; immune response; negative regulation of myoblast differentiation; inflammatory response; chemotaxis