Rantes Active Protein | Ccl5 active protein

Recombinant Rat Rantes (CCL5)

Cat. Num. AAA143280

• Gene Names: Ccl5; Scya5; Rantes
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Synonyms: Rantes; Recombinant Rat Rantes (CCL5); Rantes Rat; Rantes Rat Recombinant (CCL5); Small inducible cytokine A5; CCL5; T-cell-specific RANTES protein; SIS-delta; T cell- specific protein P228; TCP228; chemokine (C-C motif) ligand 5; SISd; SCYA5; RANTES; D17S136E; MGC17164; rRantes; Ccl5 active protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Form/Format: Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence: SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS
• Sequence Length: 92

• Solubility: It is recommended to reconstitute the lyophilized Rantes in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Biological Activity: The activity is determined by the ability to chemoattract total human lymphocytes and murine T-cells at a concentration between 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.
• Preparation and Storage: Lyophilized Rat Rantes although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Rat CCL5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for Ccl5 active protein

Description: Rantes Rat Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 68 amino acids and having a molecular mass of 7876 Dalton. The Rat Rantes is purified by proprietary chromatographic techniques.

Introduction: Regulated upon Activation, Normal T-cell Expressed, and Secreted or RANTES is an 8 kDa protein classified as a chemotactic cytokine or chemokine. It has recently been renamed CCL5. RANTES is chemotactic for T cells, eosinophils and basophils and plays an active role in recruiting leukocytes into inflammatory sites. With the help of particular cytokines (i.e. IL-2 and IFN-?) that are released by T cells, RANTES also induces the proliferation and activation of certain natural killer (NK) cells to form CHAK (CC-Chemokine-activated killer) cells. It is also a HIV-suppressive factor released from CD8+ T cells. This chemokine has been localized to chromosome 17 in humans.

Product Categories/Family for Ccl5 active protein

Chemokines; Rantes (CCL5)

NCBI and Uniprot Product Information

• NCBI GI #: 1711393
• NCBI GeneID: 81780
• UniProt Accession #: P50231
• Molecular Weight: 10,170 Da
• NCBI Official Full Name: C-C motif chemokine 5
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 5
• NCBI Official Symbol: Ccl5
• NCBI Official Synonym Symbols: Scya5; Rantes
• NCBI Protein Information: C-C motif chemokine 5; SIS-delta; T-cell-specific protein RANTES; regulated upon activation normal T-cell expressed and secreted; small inducible cytokine A5; small-inducible cytokine A5
• UniProt Protein Name: C-C motif chemokine 5
• Protein Family: C-C motif chemokine
• UniProt Gene Name: Ccl5
• UniProt Synonym Gene Names: Scya5
• UniProt Entry Name: CCL5_RAT

NCBI Description

may play a role in cellular response to viral infection in testicular somatic cells [RGD, Feb 2006]

Uniprot Description

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.