KGF (FGF7) Active Protein | FGF7 active protein

Recombinant Mouse KGF (FGF7)

Cat. Num. AAA4159935

• Gene Names: Fgf7; Kgf
• Purity: >95% as determined by SDS-PAGE
• Synonyms: KGF (FGF7); Recombinant Mouse KGF (FGF7); KGF; Fibroblast growth factor 7; FGF-7; Heparin-binding growth factor 7; HBGF-7; Recombinant Mouse Keratinocyte Growth Factor (FGF7); FGF7 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS
• Sequence Length: 194

• Bioactivity: The ED(50) was determined by the dose-dependent proliferation of Immortalized Human Bronchial Epithelial Cells-SV40 and was found to be <0.05ng/mL.
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for FGF7 active protein

KGF is a member of the family of fibroblast growth factors, it is secreted in large amounts by fibroblast-like stromal cells in epithelial tissues. The KGF receptor encodes a tyrosine kinase and is a member of the family of receptors binding aFGF and bFGF. Binding of KGF to its receptor is competed by aFGF and bFGF. Although KGF is a potent specific mitogen for many epithelial cells it is not so for fibroblasts and endothelial cells. KGF is thought to play an important role in the paracrine growth control of normal epithelial cells. KGF stimulates the proliferation of primary and secondary human keratinocytes to the same extent as EGF.

NCBI and Uniprot Product Information

• NCBI GI #: 6679785
• NCBI GeneID: 14178
• NCBI Accession #: NP_032034.1
• NCBI GenBank Nucleotide #: NP_032034.1
• UniProt Accession #: P36363
• Molecular Weight: 19.0 kDa
• NCBI Official Full Name: fibroblast growth factor 7
• NCBI Official Synonym Full Names: fibroblast growth factor 7
• NCBI Official Symbol: Fgf7
• NCBI Official Synonym Symbols: Kgf
• NCBI Protein Information: fibroblast growth factor 7
• UniProt Protein Name: Fibroblast growth factor 7
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: Fgf7
• UniProt Synonym Gene Names: Fgf-7; Kgf; FGF-7; HBGF-7; KGF
• UniProt Entry Name: FGF7_MOUSE

Uniprot Description

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted, signal peptide; Secreted

Cellular Component: Golgi apparatus; extracellular space; cell; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; receptor binding; fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: positive regulation of keratinocyte migration; fibroblast growth factor receptor signaling pathway; hair follicle morphogenesis; wound healing; mesenchymal cell proliferation; phospholipid biosynthetic process; positive regulation of peptidyl-tyrosine phosphorylation; positive chemotaxis; ovarian follicle development; positive regulation of cell division; positive regulation of cell proliferation; actin cytoskeleton reorganization; phosphatidylcholine biosynthetic process; surfactant homeostasis; positive regulation of epithelial cell proliferation; lung development