IP-10 Active Protein | Cxcl10 active protein
IP-10, Recombinant, Human (Interferon gamma Inducible Protein, CXCL10)
Gene Names
Cxcl10; C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
Purity
Highly Purified98% as determined by RP-HPLC, and/or reducing and non-reducing SDS-PAGE Silver Stained gelEndotoxin:
Synonyms
IP-10; Recombinant; Human (Interferon gamma Inducible Protein; CXCL10); Cxcl10 active protein
Host
E Coli
Purity/Purification
Highly Purified
98% as determined by RP-HPLC, and/or reducing and non-reducing SDS-PAGE Silver Stained gelEndotoxin:
98% as determined by RP-HPLC, and/or reducing and non-reducing SDS-PAGE Silver Stained gelEndotoxin:
Form/Format
Supplied as a lyophilized powder without additives. Reconstitute with sterile, ddH2O, 0.1% BSA or HSA to 100ug/ml
Sequence
The first five N-terminal amino acids is Val-Pro-Leu-Ser-Arg.
Biological Activity
Recombinant Human IP-10 is fully biologically active when compared to standard. The Biological activity is calculated by its ability to chemoattract human T lymphocytes at 10-100.0 ng/ml.
Endotoxin Level
0.1ng/ug (IEU/ug) of IP-10.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 3 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for Cxcl10 active protein
Among CXC chemokines, CXCL10 has been identified to play an important role in several endocrinological autoimmune diseases such as Hashimoto's thyroiditis, Graves'disease and Type 1 diabetes mellitus.The chemokine IP-10 (interferon-inducible protein of 10 kD, CXCL10) is a chemoattractant for CXCR3+ T cells, binds to the G protein-coupled receptor CXCR3, which is found mainly on activated T cells and NK cells, and plays an important role in Th1-type inflammatory diseases. IP-10 also binds to glycosaminoglycans (GAGs), an interaction thought to be important for its sequestration on endothelial and other cells
Recombinant Human IP-10 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8516 Dalton. Recombinant Human IP-10 is purified by proprietary chromatographic techniques.
Recombinant Human IP-10 produced in E.Coli is a single,non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 8516 Dalton. Recombinant Human IP-10 is purified by proprietary chromatographic techniques.
Product Categories/Family for Cxcl10 active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
8.52kD
NCBI Official Full Name
IP-10
NCBI Official Synonym Full Names
chemokine (C-X-C motif) ligand 10
NCBI Official Symbol
Cxcl10
NCBI Official Synonym Symbols
C7; IP10; CRG-2; INP10; IP-10; Ifi10; mob-1; Scyb10; gIP-10
NCBI Protein Information
C-X-C motif chemokine 10; gamma-IP10; OTTMUSP00000036425; interferon activated gene 10; small-inducible cytokine B10; interferon-gamma induced protein CRG-2; interferon-gamma-induced protein CRG-2; 10 kDa interferon gamma-induced protein; small inducible cytokine B subfamily (Cys-X-Cys), member 10
UniProt Protein Name
C-X-C motif chemokine 10
Protein Family
UniProt Gene Name
Cxcl10
UniProt Synonym Gene Names
Crg2; Ifi10; Inp10; Scyb10
UniProt Entry Name
CXL10_MOUSE
Uniprot Description
Function: In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
Subcellular location: Secreted.
Tissue specificity: Expressed in the spleen, thymus, lymph nodes and liver. Ref.5
Induction: By interferon gamma.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Research Articles on Cxcl10
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Product Notes
The Cxcl10 cxcl10 (Catalog #AAA651074) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The first five N-terminal amino acids is Val-Pro-Le u-Ser-Arg. It is sometimes possible for the material contained within the vial of "IP-10, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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