Interferon-inducible T Cell Alpha Chemoattractant Active Protein | CXCL11 active protein

Interferon-inducible T Cell Alpha Chemoattractant, Human (I-TAC)

Cat. Num. AAA634455

• Gene Names: CXCL11; IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• Purity: Molecular Biology Grade; 98% by SDS-PAGE and HPLC analysis.
• Synonyms: Interferon-inducible T Cell Alpha Chemoattractant; Human (I-TAC); CXCL11 active protein

• Host: E Coli
• Purity/Purification: Molecular Biology Grade; 98% by SDS-PAGE and HPLC analysis.
• Form/Format: Supplied as a lyophilized powder with no additives.

• Biological Activity: Determined by its ability to chemoattract IL-2 activated T-cells using a concentration range of 0.1-10.0ng/ml.
• Country of Origin: USA
• Endotoxin Level: 0.1ng/ug (1EU/ug)
• Reconstitution: Reconstitute in ddH2O to a concentration of 0.1-1.0mg/ml. This solution can be diluted into other buffered solutions or stored frozen for future use.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume by adding ddH2O. Aliquot and store at -20 degree C. Reconstituted product is stable for 3 months at -20 degree C when stored with a carrier protein (0.1% HSA or BSA). For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for CXCL11 active protein

Human Interferon-inducible T cell alpha chemoattractant (I-TAC), an 8.3kD protein containing 73 amino acid residues, is a novel non-ELR CXC chemokine.

Product Categories/Family for CXCL11 active protein

Growth Factors; Cytokines; Growth Factors-Interferon

NCBI and Uniprot Product Information

• NCBI GI #: 3219693
• NCBI GeneID: 6373
• UniProt Accession #: O14625; Q53YA3; Q92840
• Molecular Weight: 8.3kD
• NCBI Official Full Name: interferon stimulated T-cell alpha chemoattractant
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 11
• NCBI Official Symbol: CXCL11
• NCBI Official Synonym Symbols: IP9; H174; IP-9; b-R1; I-TAC; SCYB11; SCYB9B
• NCBI Protein Information: C-X-C motif chemokine 11; beta-R1; small inducible cytokine B11; small-inducible cytokine B11; interferon gamma-inducible protein 9; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11; small inducible cytokine subfamily B (Cys-X-Cys), member 9B
• UniProt Protein Name: C-X-C motif chemokine 11
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: CXCL11
• UniProt Synonym Gene Names: ITAC; SCYB11; SCYB9B; IP-9; I-TAC
• UniProt Entry Name: CXL11_HUMAN

NCBI Description

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q21.2

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; CXCR3 chemokine receptor binding; chemokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of release of sequestered calcium ion into cytosol; signal transduction; chemotaxis; inflammatory response; regulation of cell proliferation