Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded Human placenta tissue using MBS1493349 at dilution of 1:200.)
Mouse Protein-glutamine gamma-glutamyltransferase 2 Monoclonal Antibody | anti-TGM2 antibody
Mouse anti Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) monoclonal Antibody
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded Human placenta tissue using MBS1493349 at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded Human placenta tissue using MBS1493349 at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded Human Breast tissue using MBS1493349 at dilution of 1:200.)
Immunohistochemistry (IHC)
(Immunohistochemical of paraffin-embedded Human Breast tissue using MBS1493349 at dilution of 1:200.)
Western Blot (WB)
(All lanes: Mouse anti-TGM2 Monoclonal antibody at 1ug/mlLane 1: A549 whole cell lysateSecondary Goat polyclonal to Mouse IgG at 1/5000 dilutionPredicted band size:77kdObserved band size:77,62,39KDAdditional bands at:30kd)
Western Blot (WB)
(All lanes: Mouse anti-TGM2 Monoclonal antibody at 1ug/mlLane 1: A549 whole cell lysateSecondary Goat polyclonal to Mouse IgG at 1/5000 dilutionPredicted band size:77kdObserved band size:77,62,39KDAdditional bands at:30kd)
NCBI and Uniprot Product Information
NCBI Description
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
TGM2: an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation. Three alternatively spliced isoforms have been described.
Protein type: EC 2.3.2.13; Transferase
Chromosomal Location of Human Ortholog: 20q12
Cellular Component: cytosol; endoplasmic reticulum; focal adhesion; intrinsic to plasma membrane; mitochondrion
Molecular Function: metal ion binding; protein binding; protein-glutamine gamma-glutamyltransferase activity
Biological Process: apoptotic cell clearance; elevation of mitochondrial calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); peptide cross-linking; positive regulation of apoptosis; positive regulation of cell adhesion; reduction of endoplasmic reticulum calcium ion concentration
Research Articles on TGM2
Similar Products
Product Notes
The TGM2 tgm2 (Catalog #AAA1493349) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Human Protein-glutamine gamma-glutamyltransferase 2(TGM2) monoclonal Antibody reacts with Human. Other species are not tested. Please decide the specificity by homology and may cross-react with other species as described in the data sheet. AAA Biotech's Protein-glutamine gamma-glutamyltransferase 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the TGM2 tgm2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Protein-glutamine gamma-glutamyltransferase 2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
