IL19 active protein

Recombinant Human IL19

Cat. Num. AAA4159854

• Gene Names: IL19; MDA1; NG.1; ZMDA1; IL-10C
• Purity: >95% as determined by SDS-PAGE
• Synonyms: IL19; Recombinant Human IL19; Melanoma differentiation-association protein-like protein; NG.1; IL19 active protein

• Host: E Coli
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from a 0.2 um filtered solution in PBS
• Sequence Length: 177

• Bioactivity: The ED50 is 0.5-1.5 ng/mL as determined by a cell proliferation assay with the use of transfected BaF3 mouse pro-B cells with human IL-20Ralpha and human IL-20Rbeta
• Endotoxin Level: <1.0 EU/ug of recombinant protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile PBS at atleast 10ug/mL
• Preparation and Storage: The lyophilized protein is stable for at least one year from date of receipt at-70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2-8 degree C for one month, or at-20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.

Testing Data

Testing Data

Related Product Information for IL19 active protein

IL19 belongs to the IL-10 family of proinflammatory cytokines, which is composed of IL10, IL19, IL20, IL22, IL24, and IL26. IL19 is mainly expressed in monocytes and binds to the IL20 receptor complex which leads to the activation of the signal transducer and activator of transcription 3 (STAT3). It also performs up-regulation of IL6 and TNF-alpha and apoptosis induction, thus signifying its role in inflammatory responses.

NCBI and Uniprot Product Information

• NCBI GI #: 30795208
• NCBI GeneID: 29949
• NCBI Accession #: NP_037503.2
• NCBI GenBank Nucleotide #: NP_037503.2
• UniProt Accession #: Q9UHD0
• Molecular Weight: 18.0 kDa
• NCBI Official Full Name: interleukin-19 isoform 2
• NCBI Official Synonym Full Names: interleukin 19
• NCBI Official Symbol: IL19
• NCBI Official Synonym Symbols: MDA1; NG.1; ZMDA1; IL-10C
• NCBI Protein Information: interleukin-19
• UniProt Protein Name: Interleukin-19
• Protein Family: Interleukin
• UniProt Gene Name: IL19
• UniProt Synonym Gene Names: ZMDA1; IL-19
• UniProt Entry Name: IL19_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family.

Protein type: Secreted; Apoptosis; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: extracellular space; extracellular region

Molecular Function: cytokine activity

Biological Process: apoptosis; positive regulation of JAK-STAT cascade; immune response; inflammatory response; signal transduction; interleukin-6 biosynthetic process