C-X-C motif chemokine 5 protein (CXCL5) Active Protein | CXCL5 active protein

Recombinant Human C-X-C motif chemokine 5 protein (CXCL5) (Active)

Cat. Num. AAA969186

• Gene Names: CXCL5; SCYB5; ENA-78
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: C-X-C motif chemokine 5 protein (CXCL5); Recombinant Human C-X-C motif chemokine 5 protein (CXCL5) (Active); ENA-78; Epithelial-derived neutrophil-activating protein 78; Neutrophil-activating peptide ENA-78; Small-inducible cytokine B5;; CXCL5 active protein

• Host: E Coli
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized
• Sequence Positions: 41-114aa
• Sequence: AAVLRELRCV CLQTTQGVHP KMISNLQVFA IGPQCSKVEV VASLKNGKEI CLDPEAPFLK KVIQKILDGG NKEN
• Sequence Length: 114

• Species: Homo sapiens (Human)
• Biological Activity: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration of 5.0-10 ng/ml.
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Protein Note: Protein will be provided with aseptic processing and endotoxin removal.
• Preparation and Storage: Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.

SDS-PAGE

Related Product Information for CXCL5 active protein

Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. {ECO:0000269|PubMed:10095777}.

Product Categories/Family for CXCL5 active protein

Biological Active Protein; Immunology; Chemokine

NCBI and Uniprot Product Information

• NCBI GI #: 4506849
• NCBI GeneID: 6374
• NCBI Accession #: NP_002985.1
• NCBI GenBank Nucleotide #: NM_002994.4
• UniProt Accession #: P42830; Q96QE1
• Molecular Weight: 8.1 kDa
• NCBI Official Full Name: C-X-C motif chemokine 5
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 5
• NCBI Official Symbol: CXCL5
• NCBI Official Synonym Symbols: SCYB5; ENA-78
• NCBI Protein Information: C-X-C motif chemokine 5
• UniProt Protein Name: C-X-C motif chemokine 5
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: CXCL5
• UniProt Synonym Gene Names: ENA78; SCYB5

NCBI Description

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion. [provided by RefSeq, May 2013]

Uniprot Description

CXCL5: Involved in neutrophil activation. In vitro, ENA-78(8- 78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q13.3

Cellular Component: extracellular region; extracellular space

Molecular Function: chemokine activity; CXCR chemokine receptor binding

Biological Process: cell-cell signaling; chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; neutrophil mediated immunity; positive regulation of cell proliferation; response to lipopolysaccharide; signal transduction