ALDH3A1 active protein

ALDH3A1, 1-453aa, Human, His tag, E Coli (Bioactivity Validated)

Cat. Num. AAA203521

• Gene Names: ALDH3A1; ALDH3; ALDHIII
• Applications: SDS-Page
• Purity: > 95% by SDS-PAGE
• Synonyms: ALDH3A1; 1-453aa; Human; His tag; E Coli (Bioactivity Validated); Aldehyde dehydrogenase 3 family memberA1; ALDHIII; ALDH3; Aldehyde dehydrogenase 3 family; memberA1 AHD 4.AHD C; AHD4; AHDC; ALDH III; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase 3 family member A1; Aldehyde dehydrogenase 3A1; Aldehyde dehydrogenase class 3; Aldehyde dehydrogenase dimeric NADP preferring; Aldehyde dehydrogenase family 3 member A1; Aldehyde dehydrogenase family 3 subfamily A1; Aldehyde dehydrogenase isozyme 3; Aldehyde dehydrogenase type III; ALDH 3; ALDH 3A1; ALDH3 A1; ALDH3A 1; MGC10406; Stomach aldehyde dehydrogenase; Tumor associated aldehyde dehydrogenase tumor ALDH.; ALDH3A1 active protein

• Host: E Coli
• Purity/Purification: > 95% by SDS-PAGE
• Form/Format: Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.1M NaCl
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
• Sequence Length: 453

• Applicable Applications for ALDH3A1 active protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Biological Activity: Specific activity is > 5,000 pmol/min/ug. It was obtained by measuring the increase of NADPH in absorbance at 340nm resurting from the reduction of NADP at pH9.0 at 37C.
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for ALDH3A1 active protein

ALDH3A1, also known as Aldehyde dehydrogenase 3 family memberA1, is involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to uV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. Recombinant ALDH3A1 protein was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for ALDH3A1 active protein

Redox Proteins

References

Estey T., et al. (2007) Exp Eye Res. 84 (1):3-12; Bogucka M, et al. (2009) Acta Pol Pharm. 66 (5):477-82.;

NCBI and Uniprot Product Information

• NCBI GI #: 13325114
• NCBI GeneID: 218
• Molecular Weight: 52.5 kDa (473aa)
• NCBI Official Full Name: Aldehyde dehydrogenase 3 family, memberA1
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 3 family member A1
• NCBI Official Symbol: ALDH3A1
• NCBI Official Synonym Symbols: ALDH3; ALDHIII
• NCBI Protein Information: aldehyde dehydrogenase, dimeric NADP-preferring
• UniProt Protein Name: Aldehyde dehydrogenase, dimeric NADP-preferring
• Protein Family: Aldehyde dehydrogenase
• UniProt Gene Name: ALDH3A1
• UniProt Synonym Gene Names: ALDH3

NCBI Description

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Uniprot Description

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (). May play a role in preventing corneal damage caused by ultraviolet light ().