ALDH3A1 active protein

Human Recombinant ALDH3A1

Cat. Num. AAA844357

• Gene Names: ALDH3A1; ALDH3; ALDHIII
• Applications: SDS-Page
• Purity: >=95%
• Synonyms: ALDH3A1; Human Recombinant ALDH3A1; Aldehyde dehydrogenase 3 family; member A1; ALDHIII; ALDH3.; ALDH3A1 active protein

• Host: E Coli
• Purity/Purification: >=95%
• Form/Format: 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 0.1 M NaCl and 10% glycerol.; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK DLYPVINGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL PIVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH
• Sequence Length: 453

• Applicable Applications for ALDH3A1 active protein: SDS-PAGE
• Biological Activity: Specific activity is > 0.5 units/ml,
• Unit Definition: One unit will oxidize 1.0 umole of acetaldehyde to acetic acid per minute at pH 8.0 at 25 degree C in the presence of beta-NAD, potassium and thiols.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for ALDH3A1 active protein

Background: ALDH3A1, also known as Aldehyde dehydrogenase 3 family memberA1, is involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea.

Product Categories/Family for ALDH3A1 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)  

NCBI and Uniprot Product Information

• NCBI GI #: 22907049
• NCBI GeneID: 218
• NCBI Accession #: NP_000682.3
• NCBI GenBank Nucleotide #: NM_000691.4
• UniProt Accession #: P30838; Q9BT37; A8K828
• Molecular Weight: 52.5 kDa
• NCBI Official Full Name: aldehyde dehydrogenase, dimeric NADP-preferring
• NCBI Official Synonym Full Names: aldehyde dehydrogenase 3 family, member A1
• NCBI Official Symbol: ALDH3A1
• NCBI Official Synonym Symbols: ALDH3; ALDHIII
• NCBI Protein Information: aldehyde dehydrogenase, dimeric NADP-preferring
• UniProt Protein Name: Aldehyde dehydrogenase, dimeric NADP-preferring
• Protein Family: Aldehyde dehydrogenase
• UniProt Gene Name: ALDH3A1
• UniProt Synonym Gene Names: ALDH3
• UniProt Entry Name: AL3A1_HUMAN

NCBI Description

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

Uniprot Description

ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family.

Protein type: Amino Acid Metabolism - phenylalanine; EC 1.2.1.5; Amino Acid Metabolism - histidine; Amino Acid Metabolism - tyrosine; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; extracellular space; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity

Biological Process: response to drug; response to cAMP; positive regulation of cell proliferation; response to glucocorticoid stimulus; response to hypoxia; aldehyde metabolic process; response to nutrient; aging