Human deltex 3-like (Drosophila) ELISA Kit | DTX3L elisa kit

Human E3 ubiquitin-protein ligase DTX3L, DTX3L ELISA Kit

Cat. Num. AAA9320156

• Gene Names: DTX3L; BBAP
• Reactivity: Human
• Synonyms: deltex 3-like (Drosophila); Human E3 ubiquitin-protein ligase DTX3L; DTX3L ELISA Kit; Human E3 ubiquitin-protein ligase DTX3L (DTX3L) ELISA kit; BBAP; B-lymphoma- and BAL-associated protein; deltex 3-like; rhysin 2; DTX3L elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.5ng/ml-16ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for DTX3L elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of DTX3L (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 19923717
• NCBI GeneID: 151636
• NCBI Accession #: NP_612144.1
• NCBI GenBank Nucleotide #: NM_138287.3
• UniProt Accession #: Q8TDB6; Q53ZZ3; Q5MJP7; B3KWH6
• Molecular Weight: 83,554 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase DTX3L
• NCBI Official Synonym Full Names: deltex 3 like, E3 ubiquitin ligase
• NCBI Official Symbol: DTX3L
• NCBI Official Synonym Symbols: BBAP
• NCBI Protein Information: E3 ubiquitin-protein ligase DTX3L; rhysin2; rhysin 2; rhysin-2; deltex 3-like; B-lymphoma- and BAL-associated protein
• UniProt Protein Name: E3 ubiquitin-protein ligase DTX3L
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: DTX3L
• UniProt Synonym Gene Names: BBAP; Rhysin2
• UniProt Entry Name: DTX3L_HUMAN

NCBI Description

DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]

Uniprot Description

DTX3L: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. Belongs to the Deltex family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-

Chromosomal Location of Human Ortholog: 3q21.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; histone binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity

Biological Process: histone monoubiquitination; double-strand break repair; response to DNA damage stimulus