Protein deltex-1 (DTX1) Recombinant Protein | DTX1 recombinant protein

Recombinant Human Protein deltex-1 (DTX1)

Cat. Num. AAA1399292

• Gene Names: DTX1; hDx-1; RNF140
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Protein deltex-1 (DTX1); Recombinant Human Protein deltex-1 (DTX1); DTX1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-620, Full length protein
• Sequence: MSRPGHGGLMPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPPAPPLPPPPPPGGPPGALAVRPSATFTGAALWAAPAAGPAEPAPPPGAPPRSPGAPGGARTPGQNNLNRPGPQRTTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRHKGVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFPDTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAAAKA
• Sequence Length: 620

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for DTX1 recombinant protein

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity.

NCBI and Uniprot Product Information

• NCBI GI #: 41352718
• NCBI GeneID: 1840
• NCBI Accession #: NP_004407.2
• NCBI GenBank Nucleotide #: NM_004416.2
• UniProt Accession #: Q86Y01; O60630; Q9BS04
• Molecular Weight: 67,368 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase DTX1
• NCBI Official Synonym Full Names: deltex E3 ubiquitin ligase 1
• NCBI Official Symbol: DTX1
• NCBI Official Synonym Symbols: hDx-1; RNF140
• NCBI Protein Information: E3 ubiquitin-protein ligase DTX1
• UniProt Protein Name: E3 ubiquitin-protein ligase DTX1
• Protein Family: Protein DETOXIFICATION
• UniProt Gene Name: DTX1
• UniProt Synonym Gene Names: Deltex1; hDTX1

NCBI Description

Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Uniprot Description

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.