Human desmoglein 1 ELISA Kit | DSG1 elisa kit

Human desmogleins 1, Dsg-1 ELISA Kit

Cat. Num. AAA702014

• Gene Names: DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
• Reactivity: Human
• Synonyms: desmoglein 1; Human desmogleins 1; Dsg-1 ELISA Kit; CDHF4; DG1; DSG; PPKS1; SPPK1; desmosomal glycoprotein 1; pemphigus foliaceus antigen; DSG1 elisa kit

• Reactivity: Human
• Specificity: This assay has high sensitivity and excellent specificity for detection of human DNASE1L3. No significant cross-reactivity or interference between human DNASE1L3 and analogues was observed.
• Sequence Length: 1049

• Samples: Serum, Plasma, Tissue Homogenates, Cell Lysates
• Assay Type: Quantitative Sandwich
• Detection Range: 23.44 pg/ml-1500 pg/ml
• Sensitivity: 5.86 pg/ml.
• Intra-assay Precision: Intra-assay Precision (Precision within an assay): CV%<8%. Three samples of known concentration were tested twenty times on one plate to assess
• Inter-assay Precision: Inter-assay Precision (Precision between assays): CV%<10%. Three samples of known concentration were tested in twenty assays to assess.
• Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for DSG1 elisa kit

Principle of the Assay: This assay employs the quantitative sandwich enzyme immunoassay technique. Antibody specific for DNASE1L3 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and any DNASE1L3 present is bound by the immobilized antibody. After removing any unbound substances, a biotin-conjugated antibody specific for DNASE1L3 is added to the wells. After washing, avidin conjugated Horseradish Peroxidase (HRP) is added to the wells. Following a wash to remove any unbound avidin-enzyme reagent, a substrate solution is added to the wells and color develops in proportion to the amount of DNASE1L3 bound in the initial step. The color development is stopped and the intensity of the color is measured.

NCBI and Uniprot Product Information

• NCBI GI #: 119703744
• NCBI GeneID: 1828
• NCBI Accession #: NP_001933.2
• NCBI GenBank Nucleotide #: NM_001942.2
• UniProt Accession #: Q02413
• Molecular Weight: 113,748 Da
• NCBI Official Full Name: desmoglein-1 preproprotein
• NCBI Official Synonym Full Names: desmoglein 1
• NCBI Official Symbol: DSG1
• NCBI Official Synonym Symbols: DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
• NCBI Protein Information: desmoglein-1; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen
• UniProt Protein Name: Desmoglein-1
• Protein Family: Desmoglein
• UniProt Gene Name: DSG1
• UniProt Synonym Gene Names: CDHF4; DG1; DGI
• UniProt Entry Name: DSG1_HUMAN

NCBI Description

Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.