Dipeptidyl aminopeptidase-like protein 6 (DPP6) Recombinant Protein | DPP6 recombinant protein

Recombinant Human Dipeptidyl aminopeptidase-like protein 6 (DPP6), partial

Cat. Num. AAA950508

• Gene Names: DPP6; VF2; DPL1; DPPX; MRD33
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Dipeptidyl aminopeptidase-like protein 6 (DPP6); Recombinant Human Dipeptidyl aminopeptidase-like protein 6 (DPP6); partial; DPP6 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 117-865. Partial, provide the complete extracellular domain.
• Sequence: LTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNFNRQCLSCDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAKEDEEED

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for DPP6 recombinant protein

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

NCBI and Uniprot Product Information

• NCBI GI #: 86792774
• NCBI GeneID: 1804
• NCBI Accession #: NP_570629.2
• NCBI GenBank Nucleotide #: NM_130797.3
• UniProt Accession #: P42658
• Molecular Weight: 91,341 Da
• NCBI Official Full Name: dipeptidyl aminopeptidase-like protein 6 isoform 1
• NCBI Official Synonym Full Names: dipeptidyl peptidase like 6
• NCBI Official Symbol: DPP6
• NCBI Official Synonym Symbols: VF2; DPL1; DPPX; MRD33
• NCBI Protein Information: dipeptidyl aminopeptidase-like protein 6
• UniProt Protein Name: Dipeptidyl aminopeptidase-like protein 6
• Protein Family: Dipeptidyl aminopeptidase-like protein
• UniProt Gene Name: DPP6
• UniProt Synonym Gene Names: DPP VI

NCBI Description

This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Uniprot Description

Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821).