SRD5A2 blocking peptide
SRD5A2 Immunizing Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
Uniprot Description
SRD5A2: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH). A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Belongs to the steroid 5-alpha reductase family.
Protein type: Membrane protein, multi-pass; Lipid Metabolism - androgen and estrogen; Oxidoreductase; EC 1.3.1.22; Membrane protein, integral
Chromosomal Location of Human Ortholog: 2p23
Cellular Component: cell soma; endoplasmic reticulum membrane; integral to membrane
Molecular Function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity; amide binding; cholestenone 5-alpha-reductase activity; sterol 5-alpha reductase activity
Biological Process: androgen biosynthetic process; androgen metabolic process; biphenyl metabolic process; cell differentiation; cell-cell signaling; dibenzo-p-dioxin metabolic process; female genitalia development; hippocampus development; hypothalamus development; male genitalia development; male gonad development; phthalate metabolic process; response to drug; response to follicle-stimulating hormone stimulus; response to nutrient levels; response to peptide hormone stimulus; response to testosterone stimulus; steroid catabolic process
Disease: Pseudovaginal Perineoscrotal Hypospadias
Research Articles on SRD5A2
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Product Notes
The SRD5A2 srd5a2 (Catalog #AAA425730) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The SRD5A2 Immunizing Peptide reacts with Human, Rat, Dog, Pig and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: C-KMFEDYPK SRK. It is sometimes possible for the material contained within the vial of "SRD5A2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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