RNF31 / ZIBRA (C terminus) Blocking Peptide | RNF31 blocking peptide
RNF31 / ZIBRA (C terminus) Immunizing Peptide
Expected: Dog, Pig
Expected: Dog, Pig
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types. Ref.2 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14 Ref.15
Subunit structure: Interacts with MUSK
By similarity. Component of the LUBAC complex (linear ubiquitin chain assembly complex) which consists of SHARPIN, RBCK1 and RNF31. LUBAC has a MW of approximative 600 kDa suggesting a heteromultimeric assembly of its subunits. Associates with the TNF-R1 signaling complex (TNF-RSC) in a stimulation-dependent manner. Ref.2 Ref.12 Ref.13 Ref.14 Ref.16
Subcellular location: Cytoplasm
By similarity.
Tissue specificity: Expressed in both normal and transformed breast epithelial cell lines. Ref.1
Domain: The RanBP2-type zinc fingers mediate the specific interaction with ubiquitin. Ref.14 Ref.15The UBA domain mediates association with RBCK1/HOIL1 via interaction with its UBL domain. Ref.14 Ref.15RING 1 and IBR zinc-fingers catalyze the first step transfer of ubiquitin from the E2 onto RING 2, to transiently form a HECT-like covalent thioester intermediate. Ref.14 Ref.15The linear ubiquitin chain determining domain (LDD) mediates the final transfer of ubiquitin from RING 2 onto the N-terminus of a target ubiquitin. Ref.14 Ref.15
Sequence similarities: Contains 1 IBR-type zinc finger.Contains 3 RanBP2-type zinc fingers.Contains 2 RING-type zinc fingers.Contains 1 UBA domain.
Sequence caution: The sequence BAB15675.1 differs from that shown. Reason: Erroneous termination at position 1060. Translated as Glu.The sequence BAB15675.1 differs from that shown. Reason: Frameshift at position 1036. The sequence BAB15675.1 differs from that shown. Reason: Intron retention.The sequence BAB70948.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on RNF31
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Product Notes
The RNF31 rnf31 (Catalog #AAA426099) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. The RNF31 / ZIBRA (C terminus) Immunizing Peptide reacts with Tested: Human Expected: Dog, Pig and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: PGEEEERAFL VAR-C. It is sometimes possible for the material contained within the vial of "RNF31 / ZIBRA (C terminus), Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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