PNPLA3 / Adiponutrin Blocking Peptide | PNPLA3 blocking peptide

PNPLA3 / Adiponutrin Immunizing Peptide

Cat. Num. AAA426868

• Gene Names: Pnpla3; Adpn
• Reactivity: Human, Mouse, Rat, Dog, Pig
• Synonyms: PNPLA3 / Adiponutrin; PNPLA3 / Adiponutrin Immunizing Peptide; Pnpla3; patatin-like phospholipase domain containing 3; Adpn; adiponutrin; Adiponutrin; PNPLA3 blocking peptide

• Reactivity: Human, Mouse, Rat, Dog, Pig
• Form/Format: 100ug of dried peptide
• Sequence: EHDICPKVKSTN
• Sequence Length: 384

• Preparation and Storage: Shipped at ambient temperature, store at -20 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 144226245
• NCBI GeneID: 116939
• NCBI Accession #: NP_473429.2
• NCBI GenBank Nucleotide #: NM_054088.3
• Molecular Weight: 45,772 Da
• NCBI Official Full Name: patatin-like phospholipase domain-containing protein 3
• NCBI Official Synonym Full Names: patatin-like phospholipase domain containing 3
• NCBI Official Symbol: Pnpla3
• NCBI Official Synonym Symbols: Adpn
• NCBI Protein Information: patatin-like phospholipase domain-containing protein 3
• UniProt Protein Name: Patatin-like phospholipase domain-containing protein 3
• Protein Family: Patatin-like phospholipase domain-containing protein
• UniProt Gene Name: Pnpla3
• UniProt Synonym Gene Names: Adpn; iPLA2-epsilon
• UniProt Entry Name: PLPL3_MOUSE

Uniprot Description

PNPLA3: Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. Genetic variations in PNPLA3 are a cause of susceptibility to non-alcoholic fatty liver disease type 1 (NAFLD1). A condition characterized by an accumulation of excess triglyceride in the liver, a condition known as hepatic steatosis (or fatty liver), which is associated with adverse metabolic consequences, including insulin resistance and dyslipidemia. In a subset of individuals, hepatic steatosis promotes an inflammatory response in the liver, referred to as steatohepatitis, which can progress to cirrhosis and liver cancer. NAFLD is the most common form of liver disease in Western countries. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.3; Secondary Metabolites Metabolism - limonene and pinene degradation; Amino Acid Metabolism - tyrosine; Lipid Metabolism - glycerolipid; Transferase; Phospholipase; Amino Acid Metabolism - phenylalanine; Membrane protein, integral; Lipid Metabolism - glycerophospholipid

Cellular Component: integral to membrane; membrane

Molecular Function: 3-hydroxybutyryl-CoA thiolase activity; 3-ketopimelyl-CoA thiolase activity; acetyltransferase activity; acyl-CoA N-acyltransferase activity; acylglycerol O-acyltransferase activity; azetidine-2-carboxylic acid acetyltransferase activity; benzoyl acetate-CoA thiolase activity; C-acyltransferase activity; C-palmitoyltransferase activity; carnitine O-acyltransferase activity; dihydrolipoamide branched chain acyltransferase activity; dihydrolipoamide S-acyltransferase activity; diolein transacylation activity; glucosaminyl-phosphotidylinositol O-acyltransferase activity; hydrolase activity; keto acid formate lyase activity; L-2-aminoadipate N-acetyltransferase activity; malonyltransferase activity; mono-olein transacylation activity; myristoyltransferase activity; N-acetyltransferase activity; N-acyltransferase activity; N-palmitoyltransferase activity; N-succinyltransferase activity; O-acetyltransferase activity; O-acyltransferase activity; O-octanoyltransferase activity; O-palmitoyltransferase activity; O-sinapoyltransferase activity; O-succinyltransferase activity; octanoyltransferase activity; palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity; palmitoyltransferase activity; peptidyl-lysine N6-myristoyltransferase activity; peptidyl-lysine N6-palmitoyltransferase activity; phospholipase A2 activity; protein-cysteine S-acyltransferase activity; protein-cysteine S-myristoyltransferase activity; Ras palmitoyltransferase activity; S-acetyltransferase activity; S-acyltransferase activity; S-malonyltransferase activity; S-succinyltransferase activity; serine O-acyltransferase activity; sinapoyltransferase activity; sterol O-acyltransferase activity; succinyltransferase activity; transferase activity; transferase activity, transferring acyl groups; triacylglycerol lipase activity

Biological Process: lipid catabolic process; lipid metabolic process; metabolic process; triacylglycerol biosynthetic process; triacylglycerol catabolic process