Calsequestrin-2 Native Protein | dCASQ2 native protein

Dog Calsequestrin-2

Cat. Num. AAA142965

• Gene Names: CASQ2; CAL
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Calsequestrin-2; Dog Calsequestrin-2; CASQ2 Dog; Calsequestrin-2 Dog; Calsequestrin cardiac muscle isoform; CASQ2; CSQ; dCASQ2 native protein

• Host: Dog Heart
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: The protein was lyophilized from a concentrated solution (1mg/ml) containing 10mM Tris-HCl and 1mM EGTA.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 410

• Solubility: It is recommended to reconstitute the lyophilized CASQ2 in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Preparation and Storage: Lyophilized CASQ2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CASQ2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Related Product Information for dCASQ2 native protein

Description: Calsequestrin is the major calcium storage protein of the sarcoplasmic reticulum. Intraluminar Ca2+ binds to calsequestrin during diastole to prevent Ca2+ precipitation and to lower its free ionic concentration to facilitate efficient storage. During systole, Calsequestrin coordinately releases ~40-­50 Ca2+ ions per molecule for each contraction-relaxation cycle by an uncertain mechanism. Calsequestrin has been shown to be of major importance in the regulation of cardiac excitation-contraction coupling.

Product Categories/Family for dCASQ2 native protein

Recombinant & Natural Proteins; Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 115535
• NCBI GeneID: 483134
• UniProt Accession #: P12637
• Molecular Weight: 47,417 Da
• NCBI Official Full Name: Calsequestrin-2
• NCBI Official Symbol: CASQ2
• NCBI Official Synonym Symbols: CAL
• NCBI Protein Information: calsequestrin-2; calsequestrin 2 (cardiac muscle); Calsequestrin-2; calsequestrin, cardiac muscle isoform; cardiac calsequestrin
• UniProt Protein Name: Calsequestrin-2
• Protein Family: Calsequestrin
• UniProt Gene Name: CASQ2
• UniProt Entry Name: CASQ2_CANFA

Uniprot Description

calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family.

Protein type: Calcium-binding

Cellular Component: sarcoplasmic reticulum lumen; sarcoplasmic reticulum; junctional membrane complex; voltage-gated calcium channel complex; Z disc

Molecular Function: protein binding; calcium ion binding; calcium-dependent protein binding

Biological Process: protein polymerization; regulation of heart rate; sequestering of calcium ion; sarcomere organization; cardiac muscle contraction