Human DnaJ (Hsp40) homolog, subfamily C, member 3 ELISA Kit | DNAJC3 elisa kit

Human DnaJ homolog subfamily C member 3, DNAJC3 ELISA Kit

Cat. Num. AAA9336160

• Gene Names: DNAJC3; P58; HP58; ERdj6; PRKRI; P58IPK
• Reactivity: Human
• Synonyms: DnaJ (Hsp40) homolog; subfamily C; member 3; Human DnaJ homolog subfamily C member 3; DNAJC3 ELISA Kit; Human DnaJ homolog subfamily C member 3 (DNAJC3) ELISA kit; FLJ21288; HP58; P58; P58IPK; PRKRI; protein-kinase; interferon-inducible double stranded RNA dependent inhibitor; DNAJC3 elisa kit

• Reactivity: Human

• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml
• Intra-assay Precision: Intra-assay CV (%) is less than 15%.
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for DNAJC3 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only, not for drug, household, therapeutic or test applications! This kit is intended to be used for determine the level of DNAJC3 (hereafter termed "analyte") in undiluted original Human serum, plasma or tissue homogenates samples. For other sample types please contact tech support to determine compatibility with this assay. This kit is not suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 5453980
• NCBI GeneID: 5611
• NCBI Accession #: NP_006251.1
• NCBI GenBank Nucleotide #: NM_006260.4
• UniProt Accession #: Q13217; Q86WT9; Q8N4N2
• Molecular Weight: 57,580 Da
• NCBI Official Full Name: dnaJ homolog subfamily C member 3
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily C, member 3
• NCBI Official Symbol: DNAJC3
• NCBI Official Synonym Symbols: P58; HP58; ERdj6; PRKRI; P58IPK
• NCBI Protein Information: dnaJ homolog subfamily C member 3; ER-resident protein ERdj6; protein kinase inhibitor p58; protein kinase inhibitor of 58 kDa; endoplasmic reticulum DnaJ protein 6; endoplasmic reticulum DNA J domain-containing protein 6; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
• UniProt Protein Name: DnaJ homolog subfamily C member 3
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJC3
• UniProt Synonym Gene Names: P58IPK; PRKRI; ER-resident protein ERdj6; ERdj6; Protein kinase inhibitor p58
• UniProt Entry Name: DNJC3_HUMAN

NCBI Description

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

Uniprot Description

DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Protein type: Chaperone; Endoplasmic reticulum; Inhibitor; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle

Molecular Function: protein kinase inhibitor activity; chaperone binding; misfolded protein binding

Biological Process: unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; negative regulation of protein amino acid phosphorylation; proteolysis involved in cellular protein catabolic process; unfolded protein response; negative regulation of protein kinase activity; defense response to virus; negative regulation of apoptosis

Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus