Rabbit DNAJC3 Polyclonal Antibody | anti-DNAJC3 antibody

DNAJC3 Polyclonal Antibody

Cat. Num. AAA2521323

• Gene Names: DNAJC3; P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: DNAJC3; Polyclonal Antibody; DNAJC3 Polyclonal Antibody; P58; HP58; ERdj6; PRKRI; P58IPK; anti-DNAJC3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 0.9mg/mL (varies by lot)
• Sequence Length: 504

• Applicable Applications for anti-DNAJC3 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human DNAJC3
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DNAJC3 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human colon cancer tissue using DNAJC3 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-DNAJC3 antibody

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR).

NCBI and Uniprot Product Information

• NCBI GI #: 5453980
• NCBI GeneID: 5611
• NCBI Accession #: NP_006251.1
• NCBI GenBank Nucleotide #: NM_006260.4
• Molecular Weight: 57,580 Da
• NCBI Official Full Name: dnaJ homolog subfamily C member 3
• NCBI Official Synonym Full Names: DnaJ (Hsp40) homolog, subfamily C, member 3
• NCBI Official Symbol: DNAJC3
• NCBI Official Synonym Symbols: P58; HP58; ACPHD; ERdj6; PRKRI; P58IPK
• NCBI Protein Information: dnaJ homolog subfamily C member 3; ER-resident protein ERdj6; endoplasmic reticulum DNA J domain-containing protein 6; interferon-induced, double-stranded RNA-activated protein kinase inhibitor; protein kinase inhibitor of 58 kDa; protein kinase inhibitor p58; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor
• UniProt Protein Name: DnaJ homolog subfamily C member 3
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJC3
• UniProt Synonym Gene Names: P58IPK; PRKRI; ER-resident protein ERdj6; ERdj6; Protein kinase inhibitor p58
• UniProt Entry Name: DNJC3_HUMAN

NCBI Description

This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]

Uniprot Description

DNAJC3: Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity. Interacts with EIF2AK3 and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK. Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK. Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.

Protein type: Endoplasmic reticulum; Inhibitor; Chaperone; Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 13q32.1

Cellular Component: smooth endoplasmic reticulum; membrane; endoplasmic reticulum lumen; cytoplasm; vesicle

Molecular Function: protein kinase inhibitor activity; chaperone binding; misfolded protein binding

Biological Process: cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; proteolysis involved in cellular protein catabolic process; negative regulation of protein amino acid phosphorylation; unfolded protein response; negative regulation of protein kinase activity; defense response to virus; negative regulation of apoptosis

Disease: Ataxia, Combined Cerebellar And Peripheral, With Hearing Loss And Diabetes Mellitus