DnaJ homolog subfamily A member 1 (Dnaja1) Recombinant Protein | Dnaja1 recombinant protein

Recombinant Mouse DnaJ homolog subfamily A member 1 (Dnaja1)

Cat. Num. AAA955116

• Gene Names: Dnaja1; Hsj2; HSJ-2; Nedd7
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: DnaJ homolog subfamily A member 1 (Dnaja1); Recombinant Mouse DnaJ homolog subfamily A member 1 (Dnaja1); Dnaja1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-394, Full length protein
• Sequence: MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLADSKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQC
• Sequence Length: 394

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 258547146
• NCBI GeneID: 15502
• NCBI Accession #: NP_001158143.1
• NCBI GenBank Nucleotide #: NM_001164671.2
• UniProt Accession #: P63037; P54102
• Molecular Weight: 44,868 Da
• NCBI Official Full Name: dnaJ homolog subfamily A member 1
• NCBI Official Synonym Full Names: DnaJ heat shock protein family (Hsp40) member A1
• NCBI Official Symbol: Dnaja1
• NCBI Official Synonym Symbols: Hsj2; HSJ-2; Nedd7
• NCBI Protein Information: dnaJ homolog subfamily A member 1
• UniProt Protein Name: DnaJ homolog subfamily A member 1
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: Dnaja1
• UniProt Synonym Gene Names: Dnaj2; Hsj2; Hspf4; HSJ-2

NCBI Description

The protein encoded by this gene is a member of the DnaJ family, whose members act as cochaperones of heat shock protein 70. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. Mice deficient for this gene display reduced levels of activation‐induced deaminase, an enzyme that deaminates deoxycytidine at the immunoglobulin genes during immune responses. In addition, mice lacking this gene exhibit severe defects in spermatogenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Uniprot Description

Co-chaperone for HSPA8/Hsc70. Plays a role in protein transport into mitochondria via its role as co-chaperone. Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (). Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis.