Rabbit anti-Human, Mouse DNAJA1 Polyclonal Antibody | anti-DNAJA1 antibody

DNAJA1 Rabbit Polyclonal

Cat. Num. AAA768671

• Gene Names: DNAJA1; DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot, Immunohistochemistry
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: DNAJA1; Polyclonal Antibody; DNAJA1 Rabbit Polyclonal; anti-DNAJA1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 240

• Applicable Applications for anti-DNAJA1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
• Immunogen: DnaJ (Hsp40) homolog, subfamily A, member 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS768671 (DNAJA1 antibody) at dilution of 1:50)

Western Blot (WB)

(mouse lung tissue were subjected to SDS PAGE followed by western blot with MBS768671 (DNAJA1 antibody) at dilution of 1:500)

NCBI and Uniprot Product Information

• NCBI GI #: 930588912
• NCBI GeneID: 3301
• NCBI Accession #: NP_001300968.1
• NCBI GenBank Nucleotide #: NM_001314039.1
• Molecular Weight: 37,045 Da
• NCBI Official Full Name: dnaJ homolog subfamily A member 1 isoform 2
• NCBI Official Synonym Full Names: DnaJ heat shock protein family (Hsp40) member A1
• NCBI Official Symbol: DNAJA1
• NCBI Official Synonym Symbols: DJ-2; DjA1; HDJ2; HSDJ; HSJ2; HSJ-2; HSPF4; NEDD7; hDJ-2
• NCBI Protein Information: dnaJ homolog subfamily A member 1
• UniProt Protein Name: DnaJ homolog subfamily A member 1
• Protein Family: DnaJ homolog subfamily
• UniProt Gene Name: DNAJA1
• UniProt Synonym Gene Names: DNAJ2; HDJ2; HSJ2; HSPF4; HSJ-2; hDj-2
• UniProt Entry Name: DNJA1_HUMAN

NCBI Description

This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]

Uniprot Description

DNAJA1: Co-chaperone of Hsc70. Seems to play a role in protein import into mitochondria.

Protein type: Nuclear receptor co-regulator; Chaperone

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytosol; membrane; mitochondrion; nucleus; perinuclear region of cytoplasm; ubiquitin ligase complex

Molecular Function: ATP binding; chaperone binding; G-protein-coupled receptor binding; Hsp70 protein binding; low-density lipoprotein receptor binding; metal ion binding; protein binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: androgen receptor signaling pathway; DNA damage response, detection of DNA damage; negative regulation of apoptosis; negative regulation of JNK activity; negative regulation of protein ubiquitination; positive regulation of apoptosis; protein folding; regulation of protein transport; response to heat; response to unfolded protein; sperm motility; spermatogenesis