DLG4 recombinant protein

Recombinant Human DLG4 Protein

Cat. Num. AAA8248934

• Gene Names: DLG4; PSD95; SAP90; SAP-90
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: DLG4; Recombinant Human DLG4 Protein; PSD95; Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein 90; SAP-90; SAP90; DLG4 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of PBS, pH 7.4.
• Sequence: MNHKVHHHHH HMDCLCIVTT KKYRYQDEDT PPLEHSPAHL PNQANSPPVI VNTDTLEAPG YELQVNGTEG EMEYEEITLE RGNSGLGFSI AGGTDNPHIG DDPSIFITKI IPGGAAAQDG RLRVNDSILF VNEVDVREVT HSAAVEALKE AGSIVRLYVM RRKPPAEKVM EIKLIKGPKG LGFSIAGGVG NQHIPGDNSI YVTKIIEGGA AHKDGRLQIG DKILAVNSVG LEDVMHEDAV AALKNTYDVV YLKVAKPSNA YLSDSYAPPD ITTSYSQHLD NEISHSSYLG TDYPTAMTPT SPRRYSPVAK DLLGEEDIPR EPRRIVIHRG STGLGFNIVG GEDGEGIFIS FILAGGPADL SGELRKGDQI LSVNGVDLRN ASHEQAAIAL KNAGQTVTII AQYKPEEYSR FEAKIHDLRE QLMNSSLGSG TASLRSNPKR GFYIRALFDY DKTKDCGFLS QALSFRFGDV LHVIDAGDEE WWQARRVHSD SETDDIGFIP SKRRVERREW SRLKAKDWGS SSGSQGREDS VLSYETVTQM EVHYARPIII LGPTKDRAND DLLSEFPDKF GSCVPHTTRP KREYEIDGRD YHFVSSREKM EKDIQAHKFI EAGQYNSHLY GTSVQSVREV AEQGKHCILD VSANAVRRLQ AAHLHPIAIF IRPRSLENVL EINKRITEEQ ARKAFDRATK LEQEFTECFS AIVEGDSFEE IYHKVKRVIE DLSGPYIWVP ARERL
• Sequence Length: 721

• Applicable Applications for DLG4 recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for DLG4 recombinant protein

Recombinant Human DLG4 Protein is produced by our E Coli expression system and the target gene encoding Met1-Leu724 is expressed with a 6His tag at the N-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 192447426
• NCBI GeneID: 1742
• NCBI Accession #: NP_001122299.1
• NCBI GenBank Nucleotide #: NM_001128827.2
• UniProt Accession #: P78352; Q92941; Q9UKK8; B7Z1S1; G5E939
• Molecular Weight: 80,125 Da
• NCBI Official Full Name: disks large homolog 4 isoform 2
• NCBI Official Synonym Full Names: discs large MAGUK scaffold protein 4
• NCBI Official Symbol: DLG4
• NCBI Official Synonym Symbols: PSD95; SAP90; SAP-90
• NCBI Protein Information: disks large homolog 4
• UniProt Protein Name: Disks large homolog 4
• Protein Family: Disks large
• UniProt Gene Name: DLG4
• UniProt Synonym Gene Names: PSD95; PSD-95; SAP-90; SAP90
• UniProt Entry Name: DLG4_HUMAN

NCBI Description

This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B ().