Mouse discs, large homolog 1 (Drosophila) ELISA Kit | DLG1 elisa kit
Mouse Disks large homolog 1, DLG1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
DLG1: the human homologue of the Drosophila discs large tumor suppressor is an essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Interacts through its guanylate kinase-like domain with DLGAP1/2/3/4, and MAP1A. May interact with PTEN, HTR2A and LRFN1. Interacts through its PDZ domains with NMDAR2A, KV1.1, KV1.2, KV1.3, KV1.4, KV1.5, GLUR1, GPR124 and GPR125. Interacts with cytoskeleton-associated proteins EPB41 and EZR. Found in a complex with KV1.5 and CAV3. Found in a complex with APC and CTNNB1. Interacts with CDH1 through binding to PIK3R1. Forms multiprotein complexes with CASK, LIN7A, LIN7B, LIN7C, APBA1, and KCNJ12. Interacts through its guanylate kinase-like domain with KIF13B. Forms a tripartite complex composed of DLG1, MPP7 and LIN7A/C. May interact with TJAP1. Interacts with TOPK and the HTLV-1 viral Tax and HPV-18 E6 papillomavirus (HPV) oncoproteins. The alternatively spliced domain I3 corresponding to amino acids (636-669) of isoform 4 is an EPB41 binding site mediating association to membranes in polarized and non-polarized cells. The PDZ domains may also mediate association to membranes by binding to EPB41 and GPR124 together with the L27 domain that binds CASK and DLG2. The L27 domain may regulate DLG1 self-association. The N-terminal alternatively spliced region is capable of binding several SH3 domains and also moderates the level of protein oligomerization. Processes such as wound healing and tissue maintenance dictate that cells maintain dynamic control of junction assembly and disassembly. Many pathologic processes such as cancer and invasion of host cells by microbes affect these pathways. The HPV-18 E6 oncogene sequesters INADL and its paralog MPDZ as well as DLG1 and targets them for degradation, contributing to loss of polarity. Seven human isoforms produced by alternative splicing have been described.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: Golgi apparatus; microtubule; basolateral plasma membrane; T-tubule; immunological synapse; intercellular junction; lipid raft; postsynaptic membrane; cell-cell adherens junction; membrane; perinuclear region of cytoplasm; cell projection membrane; cytoplasm; basal plasma membrane; synapse; basal lamina; neuromuscular junction; lateral plasma membrane; neuron projection; internal side of plasma membrane; tight junction; endoplasmic reticulum; lateral loop; postsynaptic density; presynaptic membrane; plasma membrane; ionotropic glutamate receptor complex; cell junction; nucleus
Molecular Function: protein C-terminus binding; guanylate kinase activity; ionotropic glutamate receptor binding; protein binding; potassium channel regulator activity; mitogen-activated protein kinase kinase binding; protein complex scaffold; kinase binding; protein kinase binding; phosphatase binding; PDZ domain binding
Biological Process: lens development in camera-type eye; peristalsis; regulation of myelination; formation of immunological synapse; T cell activation; positive regulation of potassium ion transport; positive regulation of multicellular organism growth; receptor clustering; smooth muscle development; synaptic transmission; cell-cell adhesion; protein localization; regulation of protein localization; negative regulation of T cell proliferation; T cell cytokine production; ureteric bud development; positive regulation of cell proliferation; hard palate development; negative regulation of mitotic cell cycle; cortical actin cytoskeleton organization and biogenesis; negative regulation of epithelial cell proliferation; nucleotide phosphorylation; positive regulation of developmental growth; tissue morphogenesis; negative regulation of protein kinase B signaling cascade; actin filament organization; embryonic skeletal morphogenesis; establishment and/or maintenance of epithelial cell polarity; regulation of membrane potential; positive regulation of actin filament polymerization; ureteric bud branching; amyloid precursor protein metabolic process; endothelial cell proliferation; activation of protein kinase activity; lipid raft organization and biogenesis; reproductive structure development
Research Articles on DLG1
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Product Notes
The Mouse DLG1 dlg1 (Catalog #AAA9336613) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336613 ELISA Kit recognizes Mouse DLG1. It is sometimes possible for the material contained within the vial of "discs, large homolog 1 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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