Human diaphanous homolog 2 (Drosophila) ELISA Kit | DIAPH2 elisa kit
Human Protein diaphanous homolog 2, DIAPH2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
Diaphanous-2: Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. Isoform 3 interacts with RHOD in the GTP-bound form. Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. Belongs to the formin homology family. Diaphanous subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: Xq21.33
Cellular Component: Golgi apparatus; mitochondrion; intracellular membrane-bound organelle; early endosome; nucleolus; cytosol
Molecular Function: Rho GTPase binding; actin binding; receptor binding
Biological Process: oogenesis; actin filament polymerization; multicellular organismal development; female gamete generation; cytokinesis
Disease: Premature Ovarian Failure 2a
Research Articles on DIAPH2
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Product Notes
The Human DIAPH2 diaph2 (Catalog #AAA9339670) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9339670 ELISA Kit recognizes Human DIAPH2. It is sometimes possible for the material contained within the vial of "diaphanous homolog 2 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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