SDS-PAGE
Dehydrogenase/reductase SDR family member 2 (DHRS2) Recombinant Protein | DHRS2 recombinant protein
Recombinant Human Dehydrogenase/reductase SDR family member 2 (DHRS2)
Gene Names
DHRS2; HEP27; SDR25C1
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Dehydrogenase/reductase SDR family member 2 (DHRS2); Recombinant Human Dehydrogenase/reductase SDR family member 2 (DHRS2); Dehydrogenase/reductase SDR family member 2; EC=1.1.1.-; Dicarbonyl reductase HEP27; Protein D; DHRS2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-300aa; Full Length of Isoform 2
Sequence
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVVRIGFMGMSLSGRTSRNIISCRGLGSQRTVQESCPSCALQMPATSTGRTLRWQATPLGSERSGGGCVAVVPGPGA
Sequence Length
257
Species
Homo sapiens (Human)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
SDS-PAGE
SDS-PAGE
Related Product Information for DHRS2 recombinant protein
Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2-propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21.
Product Categories/Family for DHRS2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
58.5 kDa
NCBI Official Full Name
dehydrogenase/reductase SDR family member 2, mitochondrial isoform 2
NCBI Official Synonym Full Names
dehydrogenase/reductase (SDR family) member 2
NCBI Official Symbol
DHRS2
NCBI Official Synonym Symbols
HEP27; SDR25C1
NCBI Protein Information
dehydrogenase/reductase SDR family member 2, mitochondrial; protein D; dicarbonyl reductase HEP27; dehydrogenase/reductase member 2; short-chain alcohol dehydrogenase family member; short chain dehydrogenase/reductase family 25C, member 1
UniProt Protein Name
Dehydrogenase/reductase SDR family member 2, mitochondrial
Protein Family
UniProt Gene Name
DHRS2
UniProt Entry Name
DHRS2_HUMAN
Uniprot Description
DHRS2: Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication. Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.1.1.-; Oxidoreductase; EC 1.1.-.-
Chromosomal Location of Human Ortholog: 14q11.2
Cellular Component: mitochondrion; mitochondrial matrix; cytoplasm; nuclear envelope; nucleus
Molecular Function: carbonyl reductase (NADPH) activity
Biological Process: negative regulation of cell proliferation; response to toxin; C21-steroid hormone metabolic process; myeloid dendritic cell differentiation; negative regulation of apoptosis
Research Articles on DHRS2
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Product Notes
The DHRS2 dhrs2 (Catalog #AAA1301575) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-300aa; Full Length of Isoform 2. The amino acid sequence is listed below: MLSAVARGYQ GWFHPCARLS VRMSSTGIDR KGVLANRVAV VTGSTSGIGF AIARRLARDG AHVVISSRKQ QNVDRAMAKL QGEGLSVAGI VCHVGKAEDR EQLVAKALEH CGGVDFLVCS AGVNPLVGST LGTSEQIWDK ILSVNVKSPA LLLSQLLPYM ENRRGAVILV SSIAAYNPVV ALGVYNVSKT ALLGLTRTLA LELAPKDIRV NCVVPGIIKT DFSKVVRIGF MGMSLSGRTS RNIISCRGLG SQRTVQESCP SCALQMPATS TGRTLRWQAT PLGSERSGGG CVAVVPGPGA. It is sometimes possible for the material contained within the vial of "Dehydrogenase/reductase SDR family member 2 (DHRS2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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