Desmin Recombinant Protein | DES recombinant protein

Desmin protein

Cat. Num. AAA836372

• Gene Names: DES; CSM1; CSM2; LGMD2R
• Purity: > 95% pure
• Synonyms: Desmin; Desmin protein; FLJ39719 protein; FLJ12025 protein; CMD1I protein; FLJ41793 protein; CSM2 protein; FLJ41013 protein; DES protein; CSM1 protein; DES recombinant protein

• Host: E Coli
• Purity/Purification: > 95% pure
• Form/Format: Reconstitute with 70 ul distilled water. Fian lsolution 30mM Tris/HCI with 9.5 M urea, 2mM DTT, 2mM EDTA, 10mM Methylammonium Chloride . Final protein concentration 1.0 mg/ml

• Grade: Highly Pure
• Biohazard: Not for human use, use normal laboratory precautions when handling reagent. For research purposes only.
• Biological significance: Desmin is a protein that in humans is encoded by the DES gene. It is a type III intermediate filament found near the Z line in sarcomeres. Desmin is a 52 kDa protein that is a subunit of intermediate filaments in skeletal muscle tissue, smooth muscle tissue, and cardiac muscle tissue.
• Preparation and Storage: Upon receipt store at 4°C lyphilized. After reconstitution keep at -20°C.

Product Categories/Family for DES recombinant protein

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 55749932
• NCBI GeneID: 1674
• NCBI Accession #: NP_001918.3
• NCBI GenBank Nucleotide #: NM_001927.3
• UniProt Accession #: P17661; Q15787; Q549R7; Q549R8; Q549R9; Q8IZR1; Q8IZR6; Q8NES2; Q8NEU6; Q8TAC4; Q8TCX2; Q8TD99
• Molecular Weight: 55 kDa
• NCBI Official Full Name: desmin
• NCBI Official Synonym Full Names: desmin
• NCBI Official Symbol: DES
• NCBI Official Synonym Symbols: CSM1; CSM2; LGMD2R
• NCBI Protein Information: desmin
• UniProt Protein Name: Desmin
• Protein Family: Desmin
• UniProt Gene Name: DES
• UniProt Entry Name: DESM_HUMAN

NCBI Description

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. [provided by RefSeq, Jul 2008]

Uniprot Description

desmin: a class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: intermediate filament; fascia adherens; neuromuscular junction; cytosol; Z disc; sarcolemma

Molecular Function: identical protein binding; protein binding; structural constituent of cytoskeleton; cytoskeletal protein binding

Biological Process: muscle contraction; cytoskeleton organization and biogenesis; regulation of heart contraction; muscle filament sliding

Disease: Cardiomyopathy, Dilated, 1i; Scapuloperoneal Syndrome, Neurogenic, Kaeser Type; Myopathy, Myofibrillar, 1; Muscular Dystrophy, Limb-girdle, Type 2r