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SDS-Page

XTP3TPA Recombinant Protein | DCTPP1 recombinant protein

XTP3TPA Protein, Human, Recombinant (His Tag)

Gene Names
DCTPP1; CDA03; RS21C6; XTP3TPA
Purity
>90% as determined by SDS-PAGE
Synonyms
XTP3TPA; XTP3TPA Protein; Human; Recombinant (His Tag); Human XTP3TPA/DCTPP1 Protein (His Tag); CDA03 Protein; RS21C6 Protein; dCTP pyrophosphatase 1; DCTPP1 recombinant protein
Ordering
For Research Use Only!
Host
E Coli
Purity/Purification
>90% as determined by SDS-PAGE
Form/Format
Lyophilized from sterile 50mM Tris, 10% Glycerol, 100mM NaCl, pH8.0. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
Sequence
Met1-Thr170
Species
Human
Predicted N Terminal
His
Tag
N-His
Protein Construction
A DNA sequence encoding the mature form of human XTP3TPA(NP_077001.1)(Met1-Thr170) was expressed with a polyhistidine tag at the N-terminus.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.

SDS-Page

SDS-Page
Related Product Information for DCTPP1 recombinant protein
Background: DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1's activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. It may protect DNA or RNA against the incorporation of non-canonical nucleotide triphosphates. DCTPP1 may also protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.
References
Stelzl U. et al., 2005, Cell. 122 (6): 957-68. Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903. Moroz OV. et al., 2005, J Mol Biol. 347 (2): 243-55.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
18,681 Da
NCBI Official Full Name
dCTP pyrophosphatase 1
NCBI Official Synonym Full Names
dCTP pyrophosphatase 1
NCBI Official Symbol
DCTPP1
NCBI Official Synonym Symbols
CDA03; RS21C6; XTP3TPA
NCBI Protein Information
dCTP pyrophosphatase 1; XTP3-transactivated gene A protein; XTP3-transactivated protein A; dCTPase 1; deoxycytidine-triphosphatase 1
UniProt Protein Name
dCTP pyrophosphatase 1
Protein Family
UniProt Gene Name
DCTPP1
UniProt Synonym Gene Names
XTP3TPA; dCTPase 1
UniProt Entry Name
DCTP1_HUMAN

Uniprot Description

XTP3TPA: Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for modified dCTP. Activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. Hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). Does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP. May protect DNA or RNA against the incorporation of non- canonical nucleotide triphosphates. May protect cells against inappropriate methylation of CpG islands by DNA methyltransferases.

Protein type: EC 3.6.1.12

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cytosol

Molecular Function: dCTP diphosphatase activity; pyrimidine deoxyribonucleotide binding; magnesium ion binding; nucleoside-triphosphate diphosphatase activity

Biological Process: nucleoside triphosphate catabolic process; protein homotetramerization

Research Articles on DCTPP1

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Product Notes

The DCTPP1 dctpp1 (Catalog #AAA8121738) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Met1-Thr17 0. It is sometimes possible for the material contained within the vial of "XTP3TPA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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