Human deleted in azoospermia 3 ELISA Kit | DAZ3 elisa kit
Human Deleted in azoospermia protein 3, DAZ3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. [provided by RefSeq, Jul 2008]
Uniprot Description
DAZ3: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Defects in DAZ3 may be a cause of spermatogenic failure Y-linked type 2 (SPGFY2). It is a disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility. Belongs to the RRM DAZ family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: Yq11.223
Cellular Component: cytoplasm; nucleus
Molecular Function: RNA binding; nucleotide binding
Biological Process: multicellular organismal development; spermatogenesis; cell differentiation
Disease: Spermatogenic Failure, Y-linked, 2
Research Articles on DAZ3
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Product Notes
The Human DAZ3 daz3 (Catalog #AAA9336628) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336628 ELISA Kit recognizes Human DAZ3. It is sometimes possible for the material contained within the vial of "deleted in azoospermia 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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