Death-associated protein 1 Recombinant Protein | DAP1 recombinant protein

Recombinant Human Death-associated protein 1

Cat. Num. AAA9421548

• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: Death-associated protein 1; Recombinant Human Death-associated protein 1; DAP1 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 2-102aa

• Tag Info: GST-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for DAP1 recombinant protein

Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.

NCBI and Uniprot Product Information

• NCBI GI #: 634743288
• NCBI GeneID: 1611
• NCBI Accession #: NP_001278892.1
• NCBI GenBank Nucleotide #: NM_001291963.1
• UniProt Accession #: P51397; Q6FGC3; Q9BUC9
• Molecular Weight: 38.4kD
• NCBI Official Full Name: death-associated protein 1 isoform 1
• NCBI Official Synonym Full Names: death associated protein
• NCBI Official Symbol: DAP
• NCBI Protein Information: death-associated protein 1
• UniProt Protein Name: Death-associated protein 1
• Protein Family: Damage response protein
• UniProt Gene Name: DAP
• UniProt Synonym Gene Names: DAP1; DAP-1

NCBI Description

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Uniprot Description

DAP: a 15 kDa, proline rich protein that possesses one SH3 binding motif. Negatively regulates autophagy and is involved in mediating interferon-gamma-induced cell death. Localizes in the cytoplasm, but the detailed mechanism of its proapoptotic function is unclear.

Protein type: Autophagy

Chromosomal Location of Human Ortholog: 5p15.2

Biological Process: apoptosis; caspase activation; cellular response to amino acid starvation; inhibition of NF-kappaB transcription factor; negative regulation of autophagy; negative regulation of transcription, DNA-dependent