Human DAB2 interacting protein ELISA Kit | DAB2IP elisa kit
Human Disabled homolog 2-interacting protein, DAB2IP ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Uniprot Description
DAB2IP: Functions as a Ras GTPase-activating protein. Through its interaction with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK- NF-kappa-B signaling. May act as a tumor suppressor gene. A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; GAPs, Ras; GAPs
Chromosomal Location of Human Ortholog: 9q33.1-q33.3
Cellular Component: cell soma; endocytic vesicle; axon; cytoplasm; dendrite; plasma membrane
Molecular Function: identical protein binding; protein homodimerization activity; protein phosphatase 2A binding; mitogen-activated protein kinase kinase binding; death receptor binding; mitogen-activated protein kinase kinase kinase binding; protein kinase binding; protein binding; vascular endothelial growth factor receptor 2 binding; protein complex binding; phosphoinositide 3-kinase binding; SH3 domain binding; kinase binding; phosphatidylinositol 3-phosphate binding
Biological Process: negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of MAP kinase activity; positive regulation of JNK activity; regulation of protein heterodimerization activity; positive regulation of apoptosis; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; activation of JNK activity; negative regulation of cell proliferation; negative regulation of phosphoinositide 3-kinase activity; positive regulation of MAPKKK cascade; negative regulation of protein amino acid phosphorylation; regulation of growth; negative regulation of Ras protein signal transduction; regulation of protein complex assembly; angiogenesis; inflammatory response; regulation of I-kappaB kinase/NF-kappaB cascade; layer formation in the cerebral cortex; negative regulation of epithelial cell proliferation; negative regulation of vascular endothelial growth factor receptor signaling pathway; transformed cell apoptosis; lumen formation; negative regulation of I-kappaB kinase/NF-kappaB cascade; cell cycle; negative regulation of angiogenesis; unfolded protein response, activation of signaling protein activity; induction of apoptosis via death domain receptors; inhibition of NF-kappaB transcription factor; cellular protein catabolic process; negative regulation of fibroblast proliferation; negative regulation of toll-like receptor 4 signaling pathway; activation of MAPKKK activity; positive regulation of protein catabolic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter; I-kappaB phosphorylation; negative regulation of transcription, DNA-dependent; cell locomotion involved in cerebral cortex radial glia guided migration; neurite morphogenesis; negative regulation of phosphoinositide 3-kinase cascade
Research Articles on DAB2IP
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Product Notes
The Human DAB2IP dab2ip (Catalog #AAA9342207) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9342207 ELISA Kit recognizes Human DAB2IP. It is sometimes possible for the material contained within the vial of "DAB2 interacting protein, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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