CXCL17 recombinant protein

CXCL17, 22-119aa, Human, His tag, E Coli (Denatured)

Cat. Num. AAA205677

• Gene Names: CXCL17; DMC; VCC1; Dcip1; VCC-1; UNQ473
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: CXCL17; 22-119aa; Human; His tag; E Coli (Denatured); Chemokine (C-X-C motif) ligand 17; Dcip1; DMC; MGC138300; uNQ473; VCC-1; VCC1; CXCL17 recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL
• Sequence Length: 119

• Applicable Applications for CXCL17 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for CXCL17 recombinant protein

Chemokine (C-X-C motif) ligand 17, also known as CXCL17, is a small cytokine belonging to the CXC chemokine family. CXCL17 is a 119 amino acid secreted protein that plays a role in angiogenesis. CXCL17 is expressed in skeletal muscle, trachea, lung, intestine and stomach, and is upregulated in duodenal mucosa of patients with acute cholera, as well as breast tumors. CXCL17 is considered a housekeeping chemokine for the movement of immature dendritic cells and non activated blood monocytes into tissues, and is thought to be involved in the innate immune response. Recombinant human CXCL17 protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for CXCL17 recombinant protein

Hormones & Cytokines

References

Weinstein E J., et al. (2006) Biochem Biophys Res Commun. 350:74-81.; Hiraoka N., et al. (2011) Gastroenterology. 140:310-321.;

NCBI and Uniprot Product Information

• NCBI GI #: 38348270
• NCBI GeneID: 284340
• NCBI Accession #: NP_940879
• NCBI GenBank Nucleotide #: NM_198477.2
• UniProt Accession #: Q6UXB2; A8KAC0
• Molecular Weight: 13.7 kDa (119aa)
• NCBI Official Full Name: C-X-C motif chemokine 17
• NCBI Official Synonym Full Names: C-X-C motif chemokine ligand 17
• NCBI Official Symbol: CXCL17
• NCBI Official Synonym Symbols: DMC; VCC1; Dcip1; VCC-1; UNQ473
• NCBI Protein Information: C-X-C motif chemokine 17
• UniProt Protein Name: C-X-C motif chemokine 17
• Protein Family: VEGF coregulated chemokine
• UniProt Gene Name: CXCL17
• UniProt Synonym Gene Names: VCC1; DMC

NCBI Description

The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

Chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells (PubMed:16455961, PubMed:23115081). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). Activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions (PubMed:25411203).