CXCL17 recombinant protein

CXCL17 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8120541

• Gene Names: CXCL17; DMC; VCC1; Dcip1; VCC-1; UNQ473
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CXCL17; CXCL17 Protein; Human; Recombinant (His Tag); Human CXCL17 Protein (His Tag); Dcip1 Protein; DMC Protein; UNQ473 Protein; VCC-1 Protein; VCC1 Protein; chemokine (C-X-C motif) ligand 17; CXCL17 recombinant protein

• Host: Yeast
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, 7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Leu24-Leu119

• Species: Human
• Predicted N Terminal: Leu 24
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human CXCL17 (NP_940879.1)(Leu24-Leu119) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CXCL17 recombinant protein

Background: Chemokine (C-X-C motif) ligand 17 (CXCL17) is the latest member of the chemokine family. CXCL17 is a potential oncogene and promising therapeutic target, is an independent biomarker of poor prognosis in patients with breast cancer, and can promote proliferation and migration of breast cancer cells in vitro and in vivo. CXCL17 is expressed in a variety of cancers and promotes tumor progression by recruiting myeloid-derived suppressor cells (MDSCs). CXCL17 attenuates IMQ-induced psoriasis-like skin inflammation by recruiting MDSCs and Tregs, which may be important for regulating excessive inflammation in psoriasis skin. CXCL17 production correlated with adverse immune infiltration and might be an important target for anti-HCC therapies. CXCL17 is a major regulator of mucosal inflammatory responses.

NCBI and Uniprot Product Information

• NCBI GI #: 38348270
• NCBI GeneID: 284340
• NCBI Accession #: NP_940879.1
• NCBI GenBank Nucleotide #: NM_198477.1
• UniProt Accession #: Q6UXB2; A8KAC0
• Molecular Weight: 13,819 Da
• NCBI Official Full Name: VEGF coregulated chemokine 1
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 17
• NCBI Official Symbol: CXCL17
• NCBI Official Synonym Symbols: DMC; VCC1; Dcip1; VCC-1; UNQ473
• NCBI Protein Information: VEGF coregulated chemokine 1; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; dendritic cell and monocyte chemokine-like protein
• UniProt Protein Name: VEGF coregulated chemokine 1
• Protein Family: VEGF coregulated chemokine
• UniProt Gene Name: CXCL17
• UniProt Synonym Gene Names: VCC1; DMC
• UniProt Entry Name: VCC1_HUMAN

Uniprot Description

CXCL17: Plays a role in angiogenesis and possibly in the development of tumors. May be a housekeeping chemokine regulating recruitment of nonactivated blood monocytes and immature dendritic cells into tissues. May play a role in the innate defense against infections. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular region

Biological Process: angiogenesis; cell differentiation; chemotaxis