CXCL13 recombinant protein

RECOMBINANT HUMAN CXCL13

Cat. Num. AAA232307

• Gene Names: CXCL13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• Applications: Functional Assay
• Purity: >98% by SDS PAGE and HPLC sequence analysis
• Synonyms: CXCL13; RECOMBINANT HUMAN CXCL13; CXCL13 recombinant protein

• Purity/Purification: >98% by SDS PAGE and HPLC sequence analysis
• Form/Format: Purified recombinant protein - lyophilised
• Concentration: Approximate Protein Concentration: 0.1 mg/ml (varies by lot)
• Sequence Length: 109

• Applicable Applications for CXCL13 recombinant protein: Functional Assays (FN)
• Application Notes: Functional Assays: Minimum Dilution: 1ng/ml; Maximum Dilution: 10ng/ml
• Reconstitution: Reconstitute with 0.2ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.; Preparation
• Target Species: Human
• Preparation and Storage: Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 3 months from date of reconstitution.

Related Product Information for CXCL13 recombinant protein

Human CXCL13 also known as "B cell attracting chemokine I/BCA-1" is a chemokine in the CXC family.CXCL13 is highly effective as an attractor of B lymphocytes that express BLR-1.

NCBI and Uniprot Product Information

• NCBI GI #: 5453577
• NCBI GeneID: 10563
• NCBI Accession #: NP_006410.1
• NCBI GenBank Nucleotide #: NM_006419.2
• UniProt Accession #: O43927
• Molecular Weight: Protein Molecular Weight: 10.1kDa (85 amino acid sequence)
• NCBI Official Full Name: C-X-C motif chemokine 13
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 13
• NCBI Official Symbol: CXCL13
• NCBI Official Synonym Symbols: BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13
• NCBI Protein Information: C-X-C motif chemokine 13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13
• UniProt Protein Name: C-X-C motif chemokine 13
• Protein Family: C-X-C motif chemokine
• UniProt Gene Name: CXCL13
• UniProt Synonym Gene Names: BCA1; BLC; SCYB13; BCA-1
• UniProt Entry Name: CXL13_HUMAN

NCBI Description

B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]

Uniprot Description

CXCL13: Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: heparin binding; fibroblast growth factor binding; CXCR3 chemokine receptor binding; chemokine activity; protein heterodimerization activity; CXCR5 chemokine receptor binding; CCR10 chemokine receptor binding; receptor agonist activity

Biological Process: chronic inflammatory response; lymphocyte chemotaxis across high endothelial venule; response to lipopolysaccharide; lymph node development; regulation of angiogenesis; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of integrin activation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; cell-cell signaling; regulation of humoral immune response; defense response to bacterium; germinal center formation; immune response; inflammatory response